Does Tezepelumab work in asthma with reduced lung capacity?

Question

Hello doctor,

I am desperate for advice. My 19-year-old daughter has had severe asthma since childhood and has already been hospitalized six times this year. Her current medications —Xolair, Prednisone, and Spiriva —are barely providing relief anymore. Her pulmonologist recently recommended Tezspire, but our insurance denied it, stating she has not “failed enough other treatments.” Her lung function test shows only 58 percent capacity, and she is missing college classes every week. The asthma attacks are becoming more severe—last week, she turned blue before the ambulance arrived. We are concerned about the delay, as the appeal process is taking too long, and she is suffering daily. I’m also worried about potential immune suppression with Tezspire since she is prone to infections. Is Tezspire truly more effective than other biologics in such cases? Do you have any advice on how to convince the insurance company that it is medically necessary, or are there alternative treatments we should consider? She is starting to lose hope and is even thinking about dropping out of college.

Please help.

Thank you.

Answer 1

Hello,

Welcome to icliniq.com.

I understand your concern.

Tezspire (Tezepelumab) is a game changer as it blocks TSLP (thymic stromal lymphopoietin), which activates all types of asthma and allergic reactions. It works for both eosinophilic and non-eosinophilic allergic reactions. It reduces hospital and ER (emergency room) visits, reduces airway inflammation, and improves breathing.

You can appeal for Tezspire (Tezepelumab) by peer-to-peer review.
Backup options: Tezspire bridge program and switching to a biologic.

Tezspire has nearly no side effects and is safer for every patient.

I hope this helps.

Kindly follow up if you have more concerns.

Thank you.