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What are the side effects of weight loss medicines?

This Premium Q&A, reviewed and published, features a real conversation between an iCliniq user and a physician.

Patient's Query

Hello doctor,

I have been prescribed Rybelsus four milligrams along with Glycomet and Orlistat for weight loss. Will this medicine have side effects? According to my recent blood tests, my HbA1C is 6, and my fasting blood glucose level is 102 mg/dL.

Please help.

Answered by Dr. Thiyagarajan. T

Education:

MBBS

Professional Bio:

Dr. Thiyagarajan T is an eminent Endocrinologist specializing in the diagnosis and management of hormonal and metabolic disorders. He has expertise in diabetes, thyroid disorders, osteoporosis, adrenal and pituitary disorders, and obesity management. Known for his patient-centered approach, Dr. Thiyagarajan combines advanced diagnostic techniques with personalized treatment plans to optimize hormonal health, improve quality of life, and support long-term well-being.

This doctor is not available for online consultations on the platform anymore.

Hello,

Welcome to icliniq.com.

I understand your concern.

It appears like you want to get a second opinion about the Rybelsus (Semaglutide) medicine. I will give you a short account of possible side effects. But it is better to discuss this medicine with the doctor who prescribed you this medicine.

Rybelsus can cause nausea, vomiting, and constipation. This is a common side effect. You can overcome this by drinking water in small amounts throughout the day and 0.79 gallons per day, and eating a small portion of a low-fat diet.

Potential risks are:

  1. Worsening of eye problems like retinopathy.

  2. Do not take the medicine if you have a history of pancreatitis or if anybody in your family has medullary thyroid cancer.

If you have severe vomiting, take a lower dose and contact your doctor.

I hope this has helped you.

Please feel free to reach me again, in case of further queries.

Thank you.

Medically reviewed by iCliniq medical review team
Published At March 3, 2025
Reviewed At September 23, 2025

Education:

MBBS

Professional Bio:

Dr. Thiyagarajan T is an eminent Endocrinologist specializing in the diagnosis and management of hormonal and metabolic disorders. He has expertise in diabetes, thyroid disorders, osteoporosis, adrenal and pituitary disorders, and obesity management. Known for his patient-centered approach, Dr. Thiyagarajan combines advanced diagnostic techniques with personalized treatment plans to optimize hormonal health, improve quality of life, and support long-term well-being.

This doctor is not available for online consultations on the platform anymore.

Same symptoms don't mean you have the same problem. Consult a doctor now!

Education:

MBBS

Professional Bio:

Dr. Thiyagarajan T is an eminent Endocrinologist specializing in the diagnosis and management of hormonal and metabolic disorders. He has expertise in diabetes, thyroid disorders, osteoporosis, adrenal and pituitary disorders, and obesity management. Known for his patient-centered approach, Dr. Thiyagarajan combines advanced diagnostic techniques with personalized treatment plans to optimize hormonal health, improve quality of life, and support long-term well-being.

This doctor is not available for online consultations on the platform anymore.

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