Can Crysvita be used to treat X-linked hypophosphatemia in children?

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Crysvita (Burosumab) is a medication that is specifically designed to treat X-linked hypophosphatemia (XLH), a rare genetic disorder that affects the way the body processes phosphorus. In individuals with XLH, the body does not properly absorb phosphorus from the diet, leading to low levels of phosphorus in the blood and bones.

Crysvita works by binding to a protein called fibroblast growth factor 23 (FGF23), which is overproduced in individuals with XLH and contributes to the loss of phosphorus in the urine. By binding to FGF23, Crysvita reduces its activity, allowing the body to better absorb and retain phosphorus.

Studies have shown that Crysvita is effective in increasing serum phosphorus levels and reducing symptoms of XLH, such as bone pain, muscle weakness, and fractures. In clinical trials, Crysvita has been shown to significantly improve bone health and reduce the need for pain medication in individuals with XLH.

The dosage of Crysvita is gradually increased over several weeks to minimize side effects, which can include fever, headache, and joint pain. The long-term safety and effectiveness of Crysvita are still being studied, but initial results are promising.

While Crysvita can significantly improve the symptoms of XLH, it is important to work closely with your healthcare provider to monitor your son's response to the medication and adjust the dosage as needed. Your healthcare provider can also guide other lifestyle modifications that may help manage symptoms of XLH, such as dietary changes and exercise recommendations.

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