Hello, Welcome to icliniq.com. As per your description, your friend seems to be having sickle beta-thalassemia. It is common to see both these diseases together in communities where both diseases are prevalent. Actually, the severity of sickle cell disease comes down to the elevation of the HbF (fetal hemoglobin) component of hemoglobin, which is seen in thalassemia. Thus, high HbF will decrease the complications of sickle cell disease.
Hello,Welcome to icliniq.com.The platelet count is above the normal range. There are many reasons for such an elevated platelet count. It needs further investigations, including genetic tests.The condition like essential thrombocytosis could be considered with the available information from you.
Hi, Welcome to icliniq.com. From the medical history of your child, I can understand that she is having bleeding manifestations with normal CBC (complete blood count) and coagulation workup. I would like to know about the following questions, Since when has your daughter experienced the bleeding manifestation? Do any of your family members have a similar history in their past? Does she take any chronic medication for pain? The most common bleeding disorder is a condition known as Von Willebrand's disease. I think she needs to be checked for it, and the other condition, which needs to be evaluated, is platelet dysfunction. Investigations suggested are, VWF: Ag (Von Willebrand factor antigen) assay.
Hello, Welcome to icliniq.com. I have seen the attached reports (attachment removed to protect patient identity). Your description of the symptoms of your child seems to be significant, as the bruises are spontaneous. I would be interested to know the following points. Was there any swelling at the injection site during vaccination in her infancy? Are there any other bleeding manifestations other than bruises? Like, bleeding from the nose, gums, excess bleeding following trivial injury, etc.
Hi, Welcome to icliniq.com. From the information you provided, it seems that you have HbE beta thalassemia trait and your fiance has only Hb E trait. If so, then the chance of having a child with severe thalassemia is less. But, if you both have the same Hb E beta thalassemia trait, then there is a chance of having a beta-thalassemia major child. I would recommend you get a mutation analysis for both of you and consult a geneticist for more detailed counseling.
Hello, Welcome to icliniq.com. It is evident that you have low hemoglobin with low MCV (attachment removed to protect patient identity). Low MCV (mean corpuscular volume) means that your red blood cells (RBC) are small in size, which is more commonly seen in iron deficiency anemia. There are other conditions that show a similar laboratory profile such as thalassemia and other rare causes. As your serum iron level is normal, which probably excludes iron deficiency anemia, I would prefer you to do a blood test for thalassemia which is HPLC (High-Performance Liquid Chromatography).
Hello, Welcome to icliniq.com. After going through all the clinical details and investigation reports (attachments removed to protect the patient's identity) of your mother, it looks like she has mild anemia with chronic diseases (hypothyroidism, osteoarthritis, and hypertension). Mild anemia is expected in people with such chronic diseases which are called anemia of chronic disease, but in that case, the peripheral smear usually shows normal-sized RBCs. Such large RBC (macrocytic) can be seen in many other conditions, common among them would be vitamin B12 and folic acid deficiency. Both reports are normal.
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