As me and my fiance are carrier of Hb E beta thalassemia, we need your valuable advise.

Question

Hello doctor,

Recently, I found out that I am a carrier of HbE beta-thalassemia. The problem is that my fiance is also a carrier and he is carrying the HbE trait. We do not want to separate. If you can give us your valuable advice, then it will be a great pleasure for us.

Answer 1

Hi,

Welcome to icliniq.com.

From the information you provided, it seems that you have HbE beta thalassemia trait and your fiance has only Hb E trait. If so, then the chance of having a child with severe thalassemia is less.
But, if you both have the same Hb E beta thalassemia trait, then there is a chance of having a beta-thalassemia major child.
I would recommend you get a mutation analysis for both of you and consult a geneticist for more detailed counseling.
The option of prenatal diagnosis can be explored if you are found to be having significant issues in mutation analysis.