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What are the reasons for high platelet count?

This Premium Q&A, reviewed and published, features a real conversation between an iCliniq user and a physician.

Patient's Query

Hi doctor,

I am a 46-year-old diabetic female. My platelet count is high at 900,000 per microliter of blood in a routine CBC. My iron is normal. My USG showed hepatosplenomegaly, and PBS showed microcytic hypochromic anisocytosis.

What shall I do now?

Kindly help.
Answered by Dr. Veerendra Channabasappa Patil

Education:

MBBS

Professional Bio:

Dr. Veerendra Channabasappa Patil is a dedicated Hematologist specializing in the diagnosis and management of blood disorders. His expertise includes anemia, clotting disorders, leukemia, lymphoma, bone marrow evaluation, and patient-centered treatment planning. He is committed to providing comprehensive care, advanced diagnostics, and personalized treatment strategies for patients with complex hematological conditions.

This doctor is not available for online consultations on the platform anymore.

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Hello,

Welcome to icliniq.com.

  1. The platelet count is above the normal range. There are many reasons for such an elevated platelet count. It needs further investigations, including genetic tests.
  2. The condition like essential thrombocytosis could be considered with the available information from you. It would be wise to see the detailed blood reports.
  3. If the peripheral smear and other blood tests are fine, then genetic tests like PCR for BCR-ABL (polymerase chain reaction), JAK 2 mutation (Janus kinase), and CALR mutation (calreticulin) would be suggested.
  4. Advice, for now, would be to keep good hydration with oral fluids and get further investigations.

I hope this helps.

Medically reviewed by iCliniq medical review team
Published At March 3, 2018
Reviewed At February 5, 2026

Education:

MBBS

Professional Bio:

Dr. Veerendra Channabasappa Patil is a dedicated Hematologist specializing in the diagnosis and management of blood disorders. His expertise includes anemia, clotting disorders, leukemia, lymphoma, bone marrow evaluation, and patient-centered treatment planning. He is committed to providing comprehensive care, advanced diagnostics, and personalized treatment strategies for patients with complex hematological conditions.

This doctor is not available for online consultations on the platform anymore.

Consult other doctors in the same speciality

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Dr. Veerendra Channabasappa Patil

Hematology

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Education:

MBBS

Professional Bio:

Dr. Veerendra Channabasappa Patil is a dedicated Hematologist specializing in the diagnosis and management of blood disorders. His expertise includes anemia, clotting disorders, leukemia, lymphoma, bone marrow evaluation, and patient-centered treatment planning. He is committed to providing comprehensive care, advanced diagnostics, and personalized treatment strategies for patients with complex hematological conditions.

This doctor is not available for online consultations on the platform anymore.

Consult other doctors in the same speciality
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Read answers about:

high platelet countpolymerase chain reaction (pcr)hydrationcalr (calreticulin) mutationessential thrombocytosisjak 2 mutationperipheral smear studybcr-abl (breakpoint cluster region-abelson) test

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