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Can Amoxicillin-clavulanate and Doxycycline be taken together?

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Patient's Query

Hello doctor,

I was prescribed Amoxicillin-clavulanate and Doxycycline for my infections, both to be taken twice a day. I was wondering if I can take them at the same time.

Please help.

Answered by Dr. Georges Hany Kozah

Education:

MD

Professional Bio:

Dr. Georges Hany Kozah is an experienced Lebanese Gynecologist with an MD from The Lebanese University Faculty of Medical Sciences (2016) and a Fellowship completed in 2022. Specializing in high-risk obstetrics, advanced ultrasound, oncology, colposcopy, and hysteroscopy, he combines expertise with a patient-centered approach. Passionate about women’s health, Dr. Kozah strives for excellence and optimal outcomes in collaborative, innovative care.

This doctor is not available for online consultations on the platform anymore.

Hi,

Welcome to icliniq.com.

I have gone through your query and understand your concern.

Yes, you can generally take Amoxicillin-clavulanate and Doxycycline at the same time, unless your doctor gave you specific instructions to space them apart. There are no major interactions between the two antibiotics that would make simultaneous use unsafe.

However, a few important tips:

1. Take with food:

  • Amoxicillin-clavulanate is best taken with food to reduce stomach upset.

  • Doxycycline can also cause nausea or stomach irritation; taking it with a light meal or a full glass of water can help.

  • Avoid lying down: Stay upright for at least 30 minutes after taking Doxycycline to prevent esophageal irritation.

2. Watch for side effects: Monitor for diarrhea, yeast infections, or allergic reactions. If you experience severe side effects (like a rash, trouble breathing, or persistent diarrhea), seek medical attention.

3. Calcium, iron, and antacids: Do not take Doxycycline with dairy, calcium, magnesium, or iron supplements. They can reduce its effectiveness. If needed, space them at least two hours apart.

If you are unsure why both were prescribed or if you are treating multiple infections (like skin and sinus or tick-borne illness), it is a good idea to confirm with your prescriber to ensure you are on the best regimen. Let me know if you would like help understanding why both might be used together.

I hope I have answered your question.

Thank you.

Medically reviewed by iCliniq medical review team
Published At July 26, 2025
Reviewed At July 30, 2025

Education:

MD

Professional Bio:

Dr. Georges Hany Kozah is an experienced Lebanese Gynecologist with an MD from The Lebanese University Faculty of Medical Sciences (2016) and a Fellowship completed in 2022. Specializing in high-risk obstetrics, advanced ultrasound, oncology, colposcopy, and hysteroscopy, he combines expertise with a patient-centered approach. Passionate about women’s health, Dr. Kozah strives for excellence and optimal outcomes in collaborative, innovative care.

This doctor is not available for online consultations on the platform anymore.

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Education:

MD

Professional Bio:

Dr. Georges Hany Kozah is an experienced Lebanese Gynecologist with an MD from The Lebanese University Faculty of Medical Sciences (2016) and a Fellowship completed in 2022. Specializing in high-risk obstetrics, advanced ultrasound, oncology, colposcopy, and hysteroscopy, he combines expertise with a patient-centered approach. Passionate about women’s health, Dr. Kozah strives for excellence and optimal outcomes in collaborative, innovative care.

This doctor is not available for online consultations on the platform anymore.

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