I have positive antinuclear antibodies and have been diagnosed with mast cell activation syndrome (MCAS) and Hashimoto's disease. Kindly help.

Q. What is the reason for positive antinuclear antibodies as I am diagnosed with mast cell activation syndrome (MCAS) and Hashimoto's disease?

Answered by
Dr. Mohamad Ali Rida
and medically reviewed by iCliniq medical review team.
This is a premium question & answer published on Aug 12, 2022 and last reviewed on: Jul 21, 2023

Hello doctor,

I just received blood tests showing positive ANA tests and my doctor recommended for a rheumatologist look at my tests. The rheumatologists in my area have wait lists for six months. I was suffering from chronic fatigue, joint and nerve pain, a growing sensitivity to most foods, sensitivity to sunlight, inability to lose weight, chronic anemia, anxiety, and insomnia. The condition is progressively gotten worse for almost three years. I am diagnosed with mast cell activation syndrome (MCAS) and Hashimoto's disease. Currently, I am taking Levoxyl, Zolpidem, and Alprazolam. I have attached my complete blood count, thyroid, and immunology panel report.



Welcome to icliniq.com.

ANA (antinuclear antibodies) is a general screening test for autoimmune diseases mainly lupus. Your anemia and photosensitivity raise the concern of possible lupus, especially at your age. However, this test is not enough for diagnosis. You need more tests that can be ordered by your general physician. I recommend the following tests before any diagnosis:

  1. ENA (extractable nuclear antigen) profile.
  2. C3 and C4 (complement components).
  3. anti-ds DNA (anti-double-stranded DNA).

I strongly recommend seeing a rheumatologist. Early diagnosis means early treatment and better outcomes.

Thank you.

Hello doctor,

Thank you for the reply.

Did you take a look at the uploaded blood test results? ENA was negative, but I believe my anti-ds DNA was 27. I will request the C3 and C4 from my doctor.



Welcome back to icliniq.com.

I just saw the blood test report (attachments removed to protect the patient's identity). So basically ds-DNA and ENA are negative which is very reassuring. Positive ANA can occur in Hashimoto's disease also. I am not worried about lupus anymore however still do C3 and C4 for reassurity.

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