How do biologics work for managing spondylarthritis?

Question

Hello doctor,

My grandmother, who is 80 years old, suffers from severe pain and has been diagnosed with non-radiographic spondylarthritis. She is frequently admitted to the hospital, which is very distressing for our family. We are eager to learn about the latest treatment options for non-radiographic spondylarthritis. The doctor mentioned something about biologics, but I am unsure what that entails.

Are there effective lifestyle modifications that could help manage her condition and prevent further complications? It is heartbreaking to see her in pain, and we wonder if there are ways to stop the progression of this disease. Additionally, are there any advancements in treating older patients with arthritis that do not appear on X-rays, particularly in this year? Our goal is to help her live more comfortably and reduce the need for hospital visits.

Kindly help.

Answer 1

Hello,

Welcome to icliniq.com.

I understand your concern.

Non-radiographic spondyloarthritis, as you mentioned, does not appear on X-rays but can still cause significant inflammation, pain, and stiffness, particularly in the spine and lower back.

Treatment primarily focuses on managing inflammation, alleviating pain, and improving mobility. Biologics are newer medications designed to target inflammation at the molecular level. These medications work by blocking specific proteins in the body, such as TNF (tumor necrosis factor) or IL-17 (interleukin-17), which are central to the inflammatory process in spondyloarthritis. Biologics have been shown to effectively reduce pain, stiffness, and inflammation in patients with non-radiographic axial spondyloarthritis (nr-axSpA).

Biologics are typically administered via injection, either at home or in a healthcare setting, and require regular monitoring to ensure their effectiveness and safety. For immediate pain relief, NSAIDs (nonsteroidal anti-inflammatory drugs) are often prescribed.

Lifestyle modifications can also play a crucial role in managing this condition:

Gentle Movement: Regular, low-impact exercises can help reduce stiffness and maintain mobility. Hydrotherapy (exercises in warm water) is particularly beneficial, as the buoyancy reduces strain on the joints.
Ergonomics and Safety: Using ergonomic chairs with proper back support and supportive cushions, and installing railings in high-traffic areas of the house, can make daily activities safer and more comfortable.
Dietary Adjustments: Following an anti-inflammatory diet, such as one rich in fruits, vegetables, whole grains, and healthy fats while limiting refined sugars and red meats, can help reduce inflammation.
Stress Management: Breathing exercises, meditation, or listening to calming music can provide comfort and help alleviate stress and anxiety associated with chronic pain.

We hope these suggestions help her feel better. Please don’t hesitate to reach out with further questions. Wishing her a speedy recovery and improved comfort!

I hope that you get your answer.

Thank you.