How long does Tezepelumab take to work for asthma?

Question

Hello doctor,

My daughter has eosinophilic asthma and started Tezepelumab three months ago. It seems to be helping, but she still needs her rescue inhaler sometimes.

How long does it usually take for Tezepelumab to show full benefits?
Also, I have read that biologics can sometimes stop working over time. How would we know if she needed to switch to a different medication?
Lastly, she plays soccer. Are there any activity restrictions or things we should watch for during intense exercise?

Kindly help.

Answer 1

Hello,

Welcome to icliniq.com.

I understand your concern.

Initial improvement is often seen within a few weeks, but the full benefits can take three to six months. It works by blocking thymic stromal lymphopoietin (TSLP), which reduces airway inflammation and exacerbations.

Ongoing need for a rescue inhaler at times, especially with triggers like exercise, is not unusual early on. Biologics like Tezepelumab are generally well-tolerated long-term, but occasionally:

The body may develop antibodies that reduce effectiveness.
Asthma may progress or change, requiring a different biologic.

Signs it may not be working optimally include:

Increased use of a rescue inhaler.
More nighttime symptoms.
Worsening lung function (peak expiratory flow [PEF], spirometry).
More frequent or severe exacerbations.

Yes, physical activity is encouraged for children with asthma, especially when their condition is well-managed. Watch out for these signs:

Shortness of breath, wheezing, or coughing during or after play.
Needing the rescue inhaler before every practice or game could indicate poor control.
Fatigue or chest tightness.

Tips for safe play:

Warm-up and cool-down exercises help reduce attacks.
Avoid outdoor activity if pollution, pollen, or cold air is a trigger.

I hope you are satisfied with my answer. For further queries, you can consult me at iCliniq.

Thank you.