How to treat uncontrolled asthma effectively in older males?

Question

Hello doctor,

I am a 55-year-old male with severe asthma that has not been well controlled despite using high-dose inhaled steroids and long-acting bronchodilators. My allergist recently recommended Tezspire as a new option, since my eosinophil levels were borderline and I have had multiple exacerbations this year. I have read that Tezspire works differently from other biologics by targeting TSLP instead of IL-5 or IgE. Does that mean it could be more effective for patients like me who do not have high eosinophils? I am also concerned about potential side effects, especially infections, since I already get frequent sinus infections. How common are serious infections with Tezspire, and should I take any extra precautions while on this medication?

Please help.

Thank you.

Answer 1

Hello,

Welcome to icliniq.com.

I can understand your concern.

Tezspire (Tezepelumab) works differently from other biologics because it targets TSLP (thymic stromal lymphopoietin), not IL-5 (interleukin-5) or IgE (immunoglobulin E), which means it can help even if your eosinophil levels are borderline. Since it reduces inflammation more broadly, it is a good option for your uncontrolled asthma despite high-dose inhaled steroids and long-acting bronchodilators.

Regarding infections, serious ones are rare, but some people do experience sinus infections and sore throats. Since you are already dealing with frequent sinus infections, it is a good idea to take some extra precautions:

Keep up with your vaccinations (flu, pneumococcal, COVID-19).
Pay attention to any signs of worsening infections, and do not hesitate to check in with your doctor if something feels unusual.
Taking care of your sinuses, like using saline rinses.

Given how many flare-ups you have had this year, Tezspire could be a great option to help you gain better control over your asthma and rely less on steroids.

I hope this helps.

Kindly follow up if you have more concerns.

Thank you.