Is Tezspire safe for long-term asthma management?

Question

Hello doctor,

I am at my wits’ end with my husband’s severe asthma and need advice about Tezspire. He is 51 and has had lifelong asthma, but it has become uncontrollable over the past year. Despite using Fluticasone propionate, Tiotropium, Montelukast, and Prednisone bursts, he has been hospitalized four times in the past six months.

His pulmonologist wants to start Tezspire, but our insurance initially denied coverage, requiring him to try and fail Mepolizumab first. We finally got approval, but I am concerned about its long-term safety and effectiveness. He already has osteopenia from years of steroid use.

The self-injection process also seems intimidating, as he is not comfortable with needles. How does Tezspire differ from other biologics? Does it actually address the root cause of asthma, or does it only manage symptoms?

Additionally, the medication guide mentions parasitic infections as a risk, and we are planning an anniversary trip to Costa Rica next spring. Would that pose a concern?

Even with insurance, the cost is staggering. Is it truly worth it? Please help.

Thank you.

Answer 1

Hi,

Welcome to icliniq.com.

I read your query and can understand your concern.

Tezspire subcutaneous injection (used to treat severe asthma) is prescribed for individuals aged 12 years and above.

Yes, there have been studies indicating improvement in patients suffering from severe asthma, regardless of age. Research has been conducted on individuals between the ages of 12 and 80 years. Research papers are available if you would like to review them.

It is not an indefinite treatment course. Typically, doctors prescribe it for a duration of one year. If they observe better-than-expected improvement, they may extend the intervals between doses or prescribe a shorter course. Physicians generally aim for a treatment duration of one to two years.

Before starting Tezspire, it is important to have a detailed discussion with the treating physician to understand what to expect during the course of treatment.

In addition to the mention of parasitic infections in the medication guide, the following side effects should also be noted:

Pharyngitis (sore throat).
Arthralgia (joint pain) – This is particularly important in your husband's case since he has osteopenia. Joint pain can be severe enough to make standing for a few minutes difficult for some patients.
Back pain.
Injection-site reactions.
Headaches.

Tezspire is primarily indicated for patients with severe asthma whose symptoms remain uncontrolled despite steroid use. It is one of the newest medications available for asthma relief. While it can significantly reduce symptoms, it also comes with potential side effects. It is crucial to remain informed and discuss any concerns with a healthcare provider.

Let me know if you need any further clarification.

I hope this helps.

Kindly revert so I can assist you further.

Thank you.