Q. I want to know about the relapse regarding AIHA.

Answered by
Dr. Girish C. Kamat
and medically reviewed by iCliniq medical review team.
This is a premium question & answer published on Nov 10, 2018

Hi doctor,

I am 20 years old. I had a sudden onset of AIHA. At first, I had no response to steroid therapy, and after a week, I came back to normal. I want to know about the relapse with AIHA.



Welcome to

Approximately 80 % of patients respond to corticosteroids at a dose equivalent to Prednisolone 60 to 100 mg per day and nearly two-thirds achieve complete remission (CR). The initial response takes several weeks. But an absence of a response for 21 days is considered as a steroid failure. In responding patients, an incremental taper can begin, for example, when the Hb (hemoglobin) is more than 100 g/dL or after a maximum of three weeks, we can reduce the dose to 20 to 30 mg over four to six weeks, and then by 5 mg every month.

In a series of 33 primary AIHA (autoimmune hemolytic anemia) cases, relapse was more common if the steroids were tapered to 10 mg in less than two months and when stopped in less than six months. Approximately 20 % of patients remain in remission after steroids are discontinued. Although a further 40 % can maintain an acceptable Hb by keeping Prednisolone at 15 to 20 mg, due to the long-term side effects of steroids, and a second-line therapy is considered.

Was this answer helpful?


Same symptoms doesn’t mean you have the same problem. Consult a doctor now!

Related Questions:
Are Wysolone, HCQS, Saaz and Shelcal safe during pregnancy?

.. sulfate), Prednisolone (Wysolone), Shelcal (Calcium carbonate and Vitamin D3) are relatively safe in pregnancy and your doctor will stop Saaz (Sulfasalazine) and if possible, Wysolone too. For more information consult a rheumatologist online --&g...   Read full

My fiance's blood group and mine are different. Will it create problems to our baby's health?

And it is better to get your fiance's peripheral smear and CBC (complete blood count) done, during antenatal pregnancy period ... Hi doctor, My ...   Read full

Having kell antigens in blood during pregnancy cause any permanent effect in babies?

She has kell antigens in her blood received from a transfusion when my first son is born ... I did a blood test last week, and I also have a kell group present in my blood...   Read full

Also Read Answers From:

ideaComprehensive Medical Second Opinion.Submit your Case

Also Read

Impact of COVID-19 on Female Sexual Health
Women have been affected and still face the consequences of Coronavirus on their sexual health. Read more about the impa...  Read more»
Carpal Tunnel Syndrome in Pregnancy
Carpal tunnel syndrome in pregnancy occurs when a nerve supplying the hand is compressed at the forearm level due to the...  Read more»
Breaking the Link-Irritable Bowel Syndrome and Bacterial Overgrowth
A surplus of bacteria in the intestine causes irritable bowel syndrome (IBS). Read the article below to know more about ...  Read more»

Ask your health query to a doctor online?

Ask a Hematologist Now

* guaranteed answer within 4 hours.

Disclaimer: No content published on this website is intended to be a substitute for professional medical diagnosis, advice or treatment by a trained physician. Seek advice from your physician or other qualified healthcare providers with questions you may have regarding your symptoms and medical condition for a complete medical diagnosis. Do not delay or disregard seeking professional medical advice because of something you have read on this website. Read our Editorial Process to know how we create content for health articles and queries.