Patient's Query
Hello doctor,
My husband is 32 years old. He had three orchidopexy surgeries for bilateral undescended testes. We are now dealing with azoospermia, with normal semen volume and pH; normal testosterone levels; low inhibin B; high FSH; high LH; and 47, XYY syndrome.
Do we have a chance with micro-TESE? What other investigations should we do before micro-TESE? What is your opinion about our case?
Please advise.
Thank you.
Hello,
Welcome to icliniq.com.
I have gone through your query carefully, and I would like to know a few more details before giving a more complete opinion.
At what age was his orchidopexy performed? Early correction can sometimes improve future fertility outcomes, whereas delayed surgery may have a greater impact on sperm production. Does he have any difficulty with erections, ejaculation, or maintaining sexual function? These details are important in understanding the overall reproductive picture.
The reports you mentioned are suggestive of primary testicular failure, which means the testes themselves may not be functioning normally due to an underlying developmental or genetic abnormality. Since the testosterone levels are normal, as you mentioned, this may indicate that hormone production is still preserved to some extent. However, the sperm-producing function of the testes may be significantly reduced, resulting in azoospermia.
In this situation, micro-TESE (microsurgical testicular sperm extraction) may still provide a reasonable chance of retrieving sperm, often around 60 to 70 percent depending on the exact clinical findings and the experience of the surgical team. If sperm are successfully retrieved, the chances of conception through IVF (in vitro fertilization) or ICSI (intracytoplasmic sperm injection) would depend on multiple additional factors, including female partner fertility, embryo quality, and overall reproductive health.
However, it is essential to undergo a thorough clinical examination by your infertility specialist. They will need to assess testicular size, consistency, hormone profile, and the effect of prior surgeries to determine how feasible micro-TESE would be in his case.
I hope this helps you.
Thank you.
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Answered by Education: MCh Urology Professional Bio: Dr. Karthik Rajan is an expert in Urology. He is experienced and well-versed in all treatment modalities of Urology. This doctor is not available for online consultations on the platform anymore. Dr. Karthik Rajan
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Dr. Karthik Rajan
Urology
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