Dr. Mubashir Razzaq Khan
Hematology
The following is an actual conversation between an iCliniq user and a doctor that has been reviewed and published as a Premium Q&A.
Answered by
Medically reviewed by
Patient's Query
Hello doctor,
My platelet has always been high, in the range of 600 to 700. My other blood count is within the normal range.
Ten years ago, I had two BCR or ABL tests (peripheral blood) to rule out CML(chronic myelocytic leukemia). One test came back positive and the other negative. Which test should I believe? The first test was done with multiplex PCR with a positive result. The second test was done with qualitative reverse transcriptase - PCR with negative results.
I had a JAK2-plus test drawn with peripheral blood, and it returned positive. Based on this, the doctor diagnosed me with essential thrombocytosis. Does the presence of the JAK2-plus gene automatically rule out CML?
Hello,
Welcome to icliniq.com.
The mere presence of BCR-ABL does not confirm CML (chronic myelogenous leukemia). It has leukocytosis, splenomegaly, positive Philadelphia chromosome or other cytogenetic abnormality, BM hyperplasia, etc. A negative BCR-ABL by qRT PCR excludes it without the signs mentioned above. Moreover, a high platelet count might be part of CML instead of the only feature of CML.
However, a positive JAK2 with persistent thrombocytosis indicates essential thrombocythemia (ET). So, now you have JAK2 positive ET. Get back for treatment of ET with a fresh CBC (complete blood count).
Was this conversation helpful?
Same symptoms don't mean you have the same problem. Consult a doctor now!
Hematology
Disclaimer: No content published on this website is intended to be a substitute for professional medical diagnosis, advice or treatment by a trained physician. Seek advice from your physician or other qualified healthcare providers with questions you may have regarding your symptoms and medical condition for a complete medical diagnosis. Do not delay or disregard seeking professional medical advice because of something you have read on this website. Read our Editorial Process to know how we create content for health articles and queries.
This website uses cookies to ensure you get the best experience on our website. iCliniq privacy policy
