Recently Answered Questions
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What is BCR-ABL positive and Ph-chromosome negative?
Query: Hello doctor, Can you please explain why I would have the gene and not the chromosome? Ph-negative, BCR-ABL-positive CML. The labs pointed to this. I had bone marrow aspiration and biopsy. I saw the doctor again. From all the labs, it looks like there is CD4 and CD8 elevated ratio 16.5, 8 % NK, lymp... Read Full »
Answer: Hello, Welcome to icliniq.com. Chronic myeloid leukemia (CML) is a hematopoietic disorder, almost always characterized by the presence of the Philadelphia chromosome (Ph), usually due to t(9;22)(q34;q11) or its variants. The Ph results in the formation of the BCR/ABL1 fusion gene, which is a const... Read Full »
I have a high platelet count. what could be the reason?
Query: Hi doctor, I am a 46-year-old diabetic female. My platelet count is high at 900,000 per microliter of blood in routine CBC. My iron is normal. My USG showed hepatosplenomegaly and PBS showed microcytic hypochromic anisocytosis. What shall I do now? Read Full »
Dr. Veerendra Channabasappa Patil
Answer: Hello, Welcome to icliniq.com. The platelet count is above the normal range. There are many reasons for such elevated platelet count. It needs further investigations, including genetic tests. The conditions like essential thrombocytosis could be considered with the available information from you.... Read Full »
My platelet is always high, and one of my BCR/ABL tests was positive ten years ago. Is this CML?
Query: Hello doctor, My platelet has always been high, in the range of 600 to 700. My other blood count is within the normal range. Ten years ago, I had two BCR or ABL tests (peripheral blood) to rule out CML(chronic myelocytic leukemia). One test came back positive and the other negative. Which test shoul... Read Full »
Answer: Hello, Welcome to icliniq.com. The mere presence of BCR-ABL does not confirm CML (chronic myelogenous leukemia). It has leukocytosis, splenomegaly, positive Philadelphia chromosome or other cytogenetic abnormality, BM hyperplasia, etc. A negative BCR-ABL by qRT PCR excludes it without the signs ment... Read Full »
Are there any side effects in getting a bone marrow test?
Query: Hi doctor, My mother's age is 60 years, and six months back her WBC count was 26000. She got admitted for two days and was discharged, at that time her WBC count came to 9000. Now from the last month, she was feeling tired, so we checked the WBC count, and it was 14,000. We went to the general physi... Read Full »
Dr. Goswami Parth Rajendragiri
Answer: Hi, Welcome to icliniq.com. I have seen your attached reports (attachment removed to protect patient identity). The report shows high total count and premature WBC cells up to 13 to 14 %. It seems to be a leukemoid reaction like condition. Myeloid proliferation is present, but it does not seem t... Read Full »
Is skin whitening side effect of Gleevec permanent?
Query: Hi doctor, I have CML-CP. I am on Gleevec for the last year. My query is about skin whitening as it has turned too white. Will this side effect go away? Read Full »
Answer: Hi, Welcome to icliniq.com. Skin whitening is technically called hypopigmentation. This is the usual side effect of Gleevec (Imatinib) and is usually harmless. Usually, it is reversible once the drug is stopped. However, evidence for stopping the drug is limited and no consensus exists on drug ce... Read Full »
I am under treatment for chronic myeloid leukemia. Please give your opinion on my report.
Query: Hello doctor, I need an opinion on BCR-ABL quantitative report. I am on Imatinib for chronic myeloid leukemia. Read Full »
Dr. Goswami Parth Rajendragiri
Answer: Hello, Welcome to icliniq.com. There are no abnormal premature cells in CBC in the attached report (attachment removed to protect patient identity). So I presume that the hematological response is very good. However, I suggest further investigating the peripheral smear examination report to ... Read Full »