Bcr-abl Test

BCR-ABL is a genetic test used to detect genetic mutations on genes BCR and ABL, which are found in chromosomes 22 and 9 respectively. This mutation occurs when pieces of these genes break off and switch places. This mutation can be seen on chromosome 22, where the part of chromosome 9 gets attached.

Recently Answered Questions Recently Answered Questions

All the answers published in this website are written by Verified medical doctors, therapists and health experts. The Content has been moderated by iCliniq medical review team before publication. Post your medical clarifications on iCliniq by choosing the right specialty and get them answered. Your medical queries will be answered 24/7 by top doctors from iCliniq.

I am under treatment for chronic myeloid leukemia. Please give your opinion on my report.

Query: Hello doctor, I need an opinion on BCR-ABL quantitative report. I am on Imatinib for chronic myeloid leukemia.  Read Full »


Dr. Parth R Goswami

Family Physician, General Practitioner, Hematologist, Pathologist

Answer: Hello, Welcome to icliniq.com. There are no abnormal premature cells in CBC in the attached report (attachment removed to protect patient identity). So I presume that the hematological response is very good. However, I suggest further investigating the peripheral smear examination report to ...  Read Full »

Is skin whitening side effect of Gleevec permanent?

Query: Hi doctor, I have CML-CP. I am on Gleevec for the last one year. My query is about the skin whitening as it has turned too white. Will this side effect go away?  Read Full »


Dr. Prasad Eswaran

Hematologist, Medical Oncologist, Pain Medicine Physician, Radiotherapist

Answer: Hi, Welcome to icliniq.com. Skin whitening is technically called hypopigmentation. This is the usual side effect of Gleevec (Imatinib) and usually harmless. Usually, it is reversible once the drug is stopped. However, evidences for stopping the drug are limited and no consensus exists on drug cessat...  Read Full »

Why would I be BCR-ABL positive and Philadelphia chromosome negative?

Query: Hello doctor, Can you please explain why I would have the gene and not the chromosome? Ph-negative, BCR-ABL-positive CML. The labs pointed to this. I had bone marrow aspiration and biopsy. I saw the doctor again. From all the labs, it looks like there is CD4 and CD8 elevated ratio 16.5, 8 % NK...  Read Full »


Dr. Smrita Singh

Pathologist, Family Physician, General Practitioner, Hematologist

Answer: Hello, Welcome to icliniq.com. Chronic myeloid leukemia (CML) is a hematopoietic disorder, almost always characterized by the presence of the Philadelphia chromosome (Ph), usually due to t(9;22)(q34;q11) or its variants. The Ph results in the formation of the BCR/ABL1 fusion gene, which ...  Read Full »

Are there any side effects in getting a bone marrow test?

Query: Hi doctor, My mother's age is 60 years, and six months back her WBC count was 26000. She got admitted for two days and was discharged, at that time her WBC count came to 9000. Now from the last month, she was feeling tired, so we checked the WBC count, and it was 14,000. We went to the general p...  Read Full »


Dr. Parth R Goswami

Family Physician, General Practitioner, Hematologist, Pathologist

Answer: Hi, Welcome to icliniq.com. I have seen your attached reports (attachment removed to protect patient identity). The report shows high total count and premature WBC cells up to 13 to 14 %. It seems to be a leukemoid reaction like condition. Myeloid proliferation is present, but it does not seem to ...  Read Full »

What are the reasons for high platelet count?

Query: Hi doctor, I am a 46 year old diabetic female. My platelet count is high at 9 lakhs in routine CBC. My iron is normal. My USG showed hepatosplenomegaly and PBS showed microcytic hypochromic anisocytosis. What shall I do now?  Read Full »


Dr. Veerendra Patil

Hematologist

Answer: Hello, Welcome to icliniq.com. The platelet count is above the normal range. There are many reasons for such elevated platelet count. It needs further investigations, including genetic tests. The conditions like essential thrombocytosis could be considered with the available information from you. It...  Read Full »

My brother's leukocyte count is persistently high. Is it something of concern?

Query: Hi doctor, My brother was admitted to the hospital after he was diagnosed with dengue. However, there was concurrent evidence of severe leucocytosis (WBC >45,000 and neutrophils >70 %) and also few myelocytes and metamyelocytes. The USG of the abdomen area also revealed moderate hepatosplenome...  Read Full »


Dr. Elina Angelova Beleva

Hematologist

Answer: Hello, Welcome to icliniq.com. In case of a severe infection, an elevation of the white blood cell count (WBC) is expected and it can reach up to 100 g/L, also described as a leukemoid reaction. This is not a blood cancer and denotes the presence of mature neutrophils on the peripheral smear due to ...  Read Full »

From the attached investigations, kindly explain the condition of the patient.

Query: Hi doctor, The patient was admitted due to eight episodes of hematemesis, weight loss and loss of appetite since last six months. It was accompanied by bone pain, abdominal pain, abdominal distension, jaundice, vomiting, altered bowel habit, fever, shortness of breath, decrease urine output or al...  Read Full »


Dr. Parth R Goswami

Family Physician, General Practitioner, Hematologist, Pathologist

Answer: Hi, Welcome to icliniq.com. I had undergone the patient's reports (attachment removed to protect patient identity). First of all, the patient has a tear in esophageal mucosa because of which bleeding occurred. To prevent bleeding, I suggest vasoconstrictor agent, adrenaline injection in the mucos...  Read Full »

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Disclaimer: All health Q&As published on this website is not intended to be a substitute for professional medical diagnosis, advice or treatment by a trained physician. Seek the advice from your physician or other qualified health-care providers with questions you may have regarding your symptoms and medical condition for a complete medical diagnosis. Do not delay or disregard seeking professional medical advice because of something you have read on this website.