Common "Chronic Myeloid Leukemia" queries answered by top doctors | iCliniq

Chronic Myeloid Leukemia

Chronic myeloid leukemia (CML) is a slow progressive blood cancer. The symptoms are fast bleeding, fatigue, fever, weight loss, loss of appetite, pale skin, and night sweats. Targeted drugs (Imatinib, Dasatinib), blood stem cell transplant, chemotherapy, and biological therapy are used in the treatment.

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I am diagnosed with chronic myeloid leukemia. Please help.

Query: Hello doctor, I am 18 years old and I got told that I had chronic myeloid leukemia. Do I seriously have it? Or what do I really have? Blood test: high basophils and low hemoglobin. My symptoms are weight loss, anemia, dizziness and pale skin. Urine: leukocytes 1 to 2. And, I have a ball right under ...  Read Full »


Dr. Rathee Rahul

Answer: Hello, Welcome to icliniq.com. Well, CML (chronic myeloid leukemia) is a treatable blood cancer. The diagnosis of CML is suspected by a peripheral blood examination in which the number of basophils and eosinophils is highly raised and urine examination has no role in its diagnosis. So, on the basi...  Read Full »

How the side effects of Veenat be managed in a CML patient?

Query: Hi doctor,I am diagnosed with CML with chronic phase TLC was 4.84 lakhs and was on treatment with Hydrox. During the course of treatment, I have developed tinnitus in the right ear. When I got admitted I had severe vertigo. After the treatment, I started with Veenat 400 mg, and my count came down to...  Read Full »


Dr. Goswami Parth Rajendragiri

Answer: Hello, Welcome to icliniq.com. You have been prescribed an excellent drug for CML (chronic myeloid leukemia) which is Imatinib mesylate. This drug is considered the gold standard treatment for CML. It can lead to nausea, musculoskeletal pain, diarrhea, joint pain, pancytopenia, etc., and side effe...  Read Full »

What are the tests done to check blood cell levels?

Query: Hi doctor, I am a 35-year-old female. I have hypothyroidism and I am on Synthyroid. Overall, I am healthy. I exercise daily and do not smoke. I have a 15-month-old toddler. Throughout my pregnancy, my blood work showed an elevated WBC, but they are under 15000 per microliter of blood. They just assu...  Read Full »


Dr. Prakash. H. M.

Answer: Hi,Welcome to icliniq.com.Based on your query, my opinion is as follows:The high basophil count of 10% associated with immature granulocytes of 9.8% is a bit worrisome.The white blood cell count is unusually low for the above findings. As with the above, I expect to usually count on more than 100,00...  Read Full »

What is BCR-ABL positive and Ph-chromosome negative?

Query: Hello doctor, Can you please explain why I would have the gene and not the chromosome? Ph-negative, BCR-ABL-positive CML. The labs pointed to this. I had bone marrow aspiration and biopsy. I saw the doctor again. From all the labs, it looks like there is CD4 and CD8 elevated ratio 16.5, 8 % NK, lymp...  Read Full »


Dr. Singh Smrita

Answer: Hello, Welcome to icliniq.com. Chronic myeloid leukemia (CML) is a hematopoietic disorder, almost always characterized by the presence of the Philadelphia chromosome (Ph), usually due to t(9;22)(q34;q11) or its variants. The Ph results in the formation of the BCR/ABL1 fusion gene, which is a const...  Read Full »

My partner has elevated levels of WBC and platelets. Does it indicate chronic myeloid leukemia?

Query: Hello doctor, I am enquiring on behalf of my partner. His WBC levels have been elevated, along with fatigue and some sweating. A couple of months ago, the WBC level was 10,300 cells per microliter of blood. The most recent blood test shows a WBC of around 13,260 cells per microliter of blood. Neutro...  Read Full »


Dr. Goswami Parth Rajendragiri

Answer: Hello, Welcome to icliniq.com. I read your query and can understand your concern. I have reviewed the report (attachments removed to protect the patient's identity). There are no premature cells like myelocytes, metamyelocytes, etc. Total WBC (white blood count) is also not more than 50000 cells...  Read Full »

Is my brother's persistent high WBC a sign of concern?

Query: Hi doctor, My brother was admitted to the hospital after he was diagnosed with dengue. However, there was concurrent evidence of severe leukocytosis (WBC >45,000 and neutrophils >70 %) and also few myelocytes and metamyelocytes. The USG of the abdomen area also revealed moderate hepatosplenome...  Read Full »


Dr. Elina Angelova Beleva

Answer: Hello, Welcome to icliniq.com. In case of a severe infection, an elevation of the white blood cell count (WBC) is expected and it can reach up to 100 g/L, also described as a leukemoid reaction. This is not a blood cancer and denotes the presence of mature neutrophils on the peripheral smear due t...  Read Full »

I have bone pain, skin rash, and headache after taking Tasigna.

Query: Hello doctor, I have been diagnosed with CML PH+ and have been taking a medicine called Tasigna for the past few months. However, I have been suffering from various side effects, such as pain in my bones, headache, and skin rash. Recently, all of these symptoms have become more severe, especially th...  Read Full »


Dr. Goswami Parth Rajendragiri

Answer: Hello, Welcome to icliniq.com. I went through your query and understood your concern. Tasigna (Nilotinib) is an excellent drug available for the treatment of CML (chronic myeloid leukemia) and is a tyrosine kinase inhibitor. The mentioned side effects are because of this drug. This drug should no...  Read Full »

Kindly suggest the condition of the patient on seeing the investigations attached.

Query: Hi doctor,The patient was admitted due to eight episodes of hematemesis, weight loss, and loss of appetite in the last six months. It was accompanied by bone pain, abdominal pain, abdominal distension, jaundice, vomiting, altered bowel habit, fever, shortness of breath, decreased urine output, or al...  Read Full »


Dr. Goswami Parth Rajendragiri

Answer: Hi,Welcome to icliniq.com.I had undergone the patient's reports (attachment removed to protect patient identity).First of all, the patient has a tear in the esophageal mucosa because of which bleeding occurred. To prevent bleeding, I suggest a vasoconstrictor agent and adrenaline injection in the mu...  Read Full »

My 72-year-old father with CML has a huge increase in WBC count after taking Omacetaxine mepesuccinate shots. Kindly help.

Query: Hello doctor, My 72-year-old father has a weak heart and was diagnosed with CML. None of this worked because he has that gateway mutation. Was not a candidate for stem cells. He has been on Omacetaxine for over a year. The first round of 24 shots was way too much. He is now on six days of chemother...  Read Full »


Dr. Goswami Parth Rajendragiri

Answer: Hello, Welcome to icliniq.com. I understand your concern. Treatment of CML (chronic myeloid leukemia) depends upon the patient's clinical condition and phase of CML. Usually, patients are given Imatinib or Nilotinib-like tyrosine kinase inhibitors drugs as a first line. But in this case, there is ...  Read Full »

My platelet is always high, and one of my BCR/ABL tests was positive ten years ago. Is this CML?

Query: Hello doctor, My platelet has always been high, in the range of 600 to 700. My other blood count is within the normal range. Ten years ago, I had two BCR or ABL tests (peripheral blood) to rule out CML(chronic myelocytic leukemia). One test came back positive and the other negative. Which test shoul...  Read Full »


Dr. Mubashir Razzaq Khan

Answer: Hello, Welcome to icliniq.com. The mere presence of BCR-ABL does not confirm CML (chronic myelogenous leukemia). It has leukocytosis, splenomegaly, positive Philadelphia chromosome or other cytogenetic abnormality, BM hyperplasia, etc. A negative BCR-ABL by qRT PCR excludes it without the signs ment...  Read Full »

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