Do HR-positive or HER2-negative BC run in families?

Question

Hello doctor,

A family member has been diagnosed with HR-positive/HER2-negative breast cancer, and I would like to understand more about this type of cancer. What are the specific causes and risk factors associated with HR-positive/HER2-negative breast cancer, and how does it typically develop? Is this type of breast cancer more likely to run in families, and are there any genetic markers we should be aware of?

What are the recommended treatment options, and how effective are they for this particular subtype? Are there lifestyle changes or preventative measures that can help reduce the risk of recurrence or development in other family members?

Please help.

Answer 1

Hello,

Welcome to icliniq.com.

I understand your concern.

I am sorry to hear that.

Breast cancers are classified based on the type of receptor they express. The presence or absence of the condition affects the options of treatment available for the cancer.

HR+ (hormone receptor-positive) means the cancer has a receptor for estrogen and progesterone on it, so its growth is facilitated by these hormones. Therefore, blocking these receptors helps prevent cancer growth and can be used in the treatment of cancer.

HER2- means that human epidermal growth factor receptor 2 is absent. This protein promotes the growth of the cancer, and its absence is good for the treatment of the cancer.

So, HR+/HER2- is a common variant of breast cancer.

There are several risk factors for cancer, like obesity, diabetes, genetic predisposition, and family history, among others. However, a major risk is the family, so individuals with first and second-degree relatives with breast cancer should have genetic screening for breast cancer genes.

The treatment options for this type of cancer surgery are radiotherapy or chemotherapy, depending on the stage of the cancer. Treatment is quite effective, and the prognosis with early treatment is good for such cancers.

Obesity contributes significantly to breast cancer, so a healthy weight, a healthy diet, and compliance with follow-up self-breast examination will help to reduce the risk of recurrence and early detection of breast cancer.

I hope this is helpful.

Thank you.