How can HR-positive and HER2-negative BC be diagnosed early?

Question

Hello doctor,

I am concerned about the possibility of HR-positive or HER2-negative breast cancer in a loved one.

What are the signs and symptoms of this specific type of breast cancer, and how can it be recognized early?
Are there particular risk factors or genetic markers that we should be aware of that might increase the likelihood of developing HR-positive or HER2-negative breast cancer?
How is this type of breast cancer typically diagnosed, and what tests are used to determine the hormone receptor and HER2 status?
What should we do if we notice any concerning symptoms, and how can we work with healthcare providers to ensure early detection and effective treatment?

Please help.

Thank you.

Answer 1

Hello,

Welcome to icliniq.com.

I understand your concern.

You are concerned about the type of cancer, HR-positive or HER-2neu negative. They are a type of breast carcinoma with a good prognosis. HR-positive means this tumor is estrogen- and progesterone-hormone receptor-positive, while HER2-neu is epidermal growth factor receptor-negative.

The signs and symptoms of breast carcinoma are lumps in any quadrant of the breast, skin changes, any discharge or ulcer, nipple retraction, and swelling of lymph nodes in the axillary region (armpit).

To diagnose breast cancer, patients should undergo a triple assessment:

1. Clinical examination of both breasts and the axillary region.

2. Radiological examination.

3. Ultrasound for younger women less than 35 years of age.

4. Mammogram for older women above 40 years.

5. Histological examination.

6. Core biopsy of lump, check for hormone receptors- ER, PR, HER 2neu.

The risk factors for breast cancer are:

Family history.
Smoking.
Obesity.
Late menopause.
Early menarche.
Use of hormonal replacement therapy.

Preventive measures are-

Early detection by breast clinical examination and mammogram.
Genetic testing for BRCA1 and BRCA2.
Avoid smoking.
Weight reduction.
Exercise.

Treatment will depend on the staging of the disease, the type of tumor, and lymph node status.

I would like to have your feedback,

Kindly follow up if you have more concerns.

Thank you.