Does colon cancer risk increase in chronic inflammation?

Hello,

Welcome to icliniq.com.

I can understand your concern.

Your situation reflects moderate ulcerative colitis (UC) that is not fully controlled by current therapy. Ongoing symptoms like four to five loose stools daily, intermittent blood, and an elevated CRP (C-reactive protein) (14 mg/L) suggest that inflammation is still active despite Mesalamine and rectal enemas. In such cases, escalation to systemic therapy is often appropriate, and biologics like Infliximab or Ustekinumab are commonly used for moderate to severe UC, especially when conventional therapies fall short. The choice between biologics depends on multiple factors, including disease severity, response history, and your overall health profile.

Chronic active inflammation, particularly beyond eight to ten years of UC, increases the risk of colorectal dysplasia and cancer, especially if the disease extends beyond the rectum. Since you have had UC for five years with inflammation still present in the sigmoid and rectum, your cancer risk is lower than someone with pancolitis, but not negligible. Regular surveillance colonoscopies are usually recommended every one to two years, starting at year eight of diagnosis, or earlier if high-risk features are present (e.g., family history of CRC, primary sclerosing cholangitis, or strictures).

I hope this helps.

Kindly follow up if you have more concerns.

Thank you.