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Can long-term contraceptive gel use damage my vaginal health?

This Premium Q&A, reviewed and published, features a real conversation between an iCliniq user and a physician.

Patient's Query

Hello doctor,

I have been using this contraceptive gel called Phexxi for the past four months because I cannot take hormonal birth control due to a history of blood clots in my legs.

The gel works by changing vaginal pH, but I am getting constant yeast infections and UTIs since starting it. I had three UTIs already treated with Nitrofurantoin and Fluconazole for yeast, but they keep coming back.

The burning and itching are so bad after using the contraceptive gel that sex has become painful for my partner. My gynecologist did cultures, and everything came back normal, but symptoms persist.

I have also noticed increased vaginal discharge that has a strong chemical smell, which is embarrassing. tried switching to different applicators, thinking it might be contamination, but no improvement.

I have read on the internet that contraceptive gel can disrupt normal vaginal bacteria, but the doctor says it is rare. I am 33 and really need effective birth control since we do not want kids right now, but this is affecting my relationship and quality of life.

  1. Are there other non-hormonal options that will not cause these infections?

  2. Can long-term use of contraceptive gel cause permanent damage to vaginal health?

Please suggest.

Answered by Dr. Ali Osman

Education:

MBBS

Professional Bio:

Dr. Ali Osman is an Obstetrician and Gynecologist adept at current medical and surgical management of wide range of conditions involving the female reproducitve system. With six years of working experience in the field of obstetrics and gynecology, he has special interest in prenatal, antenatal, postnatal care, fetal medicine and precancer gynecological conditions. He is currently working in Jinnah hospital, Lahore.

This doctor is not available for online consultations on the platform anymore.

Hello,

Welcome to icliniq.com.

I understand your concern.

Phexxi works by lowering vaginal pH using lactic acid, citric acid, and potassium bitartrate. While many women tolerate it well, others, particularly those who are prone to UTIs (urinary tract infections) or yeast infections, may develop significant side effects, including:

  1. Vaginal irritation.

  2. Burning during and after intercourse.

  3. Disruption of normal lactobacilli (healthy vaginal flora).

  4. Increased vaginal discharge with an odor.

  5. Recurrent yeast infections.

  6. Increased urinary tract infections (UTIs).

Your pattern, like burning, itching, recurrent infections, and a chemical-type discharge, is very typical of Phexxi intolerance. A normal culture result does not mean that nothing is wrong. The gel itself can cause chemical vaginitis, which leads to symptoms even when no infection is present.

Phexxi does not cause permanent damage. However, repeated cycles of irritation and infection keep the vaginal microbiome disrupted as long as the irritant continues to be used.

I suggest you temporarily stop using Phexxi. Your symptoms will not fully resolve if the irritation continues; treat the current imbalance. A few things that can help you are:

  1. Boric acid vaginal suppositories, 600 mg nightly for seven to 14 days.

  2. Vaginal probiotic suppositories containing Lactobacillus crispatus.

  3. Continue yeast or UTI treatment as prescribed.

  4. Avoid douching, scented washes, Phexxi, and other acidic products. Your vaginal microbiome needs time to heal and rebalance.

Because estrogen-containing contraception is contraindicated, the following non-hormonal options are safe and effective:

  1. Copper IUD (Paragard) is over 99 percent effective and safe, with a history of blood clots. It is hormone-free and effective for up to 10 years. It does not increase yeast infections or UTIs (urinary tract infections). It may cause heavier or more painful periods initially.

  2. Diaphragm (Caya or Milex) is a reusable and hormone-free method. It is inserted only before intercourse and used with a contraceptive gel that is not acidic (unlike Phexxi). It is often well tolerated by individuals who cannot use Phexxi.

  3. A cervical cap is smaller than a diaphragm, and its effectiveness ranges from 82 to 88 percent, higher with perfect use.

  4. Male condoms (Latex or Polyurethane) protect against sexually transmitted infections and are hormone-free. It is 87 to 98 percent effective. A good temporary option while vaginal tissue heals.

  5. Female or internal condoms are hormone-free, which allows control by the receptive partner. Its effectiveness is approximately 79 to 95 percent.

If future fertility is not desired, some permanent options you can consider are:

  1. Male vasectomy, which is the safest and least invasive.

  2. Female tubal ligation, which iseffective but involves a higher surgical risk.

Because you are currently experiencing active vaginal irritation and recurrent symptoms, the priority should be healing your vaginal microbiome before deciding on a long-term contraceptive method.

I hope this helps.

Thank you.

Answered by Dr. Ali Osman
Medically reviewed by iCliniq medical review team
Published At April 6, 2026
Reviewed At April 6, 2026

Education:

MBBS

Professional Bio:

Dr. Ali Osman is an Obstetrician and Gynecologist adept at current medical and surgical management of wide range of conditions involving the female reproducitve system. With six years of working experience in the field of obstetrics and gynecology, he has special interest in prenatal, antenatal, postnatal care, fetal medicine and precancer gynecological conditions. He is currently working in Jinnah hospital, Lahore.

This doctor is not available for online consultations on the platform anymore.

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Education:

MBBS

Professional Bio:

Dr. Ali Osman is an Obstetrician and Gynecologist adept at current medical and surgical management of wide range of conditions involving the female reproducitve system. With six years of working experience in the field of obstetrics and gynecology, he has special interest in prenatal, antenatal, postnatal care, fetal medicine and precancer gynecological conditions. He is currently working in Jinnah hospital, Lahore.

This doctor is not available for online consultations on the platform anymore.

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