What is the role of calcium in blocking blood vessels?

Hi doctor,

My medical condition, background information, current lifestyle and medications are as follows. My cardiac calcium score was over 4,500 before four years and is now over 9,400. Angioplasty before six months revealed mid right coronary artery stenosis of less than 50% and diffused LAD 20% to 30% but no focal stenosis visualized. It also shows large diagonal branch from proximal segment of LAD with stenosis of 60% to 70%, left circumflex artery with 30% of stenosis at the ostium and 30% to 40% of stenosis on its proximal segment and one large obtuse marginalo visualized without significant stenosis. RCA is large and dominant. In mid distal segment of RCA there is 70% stenosis. There is moderate degree of calcification in proximal RCA. Left ventriculogram showed estimated ejection fraction of 60% to 65% with no significant wall motion abnormalities. During angioplasty interventionist was unable to place a stent and said RCA was like cement. Subsequent cardiac calcium scan revealed left main and LAD 1575, LCX 1276, RCA 6589. In pericardium there is no evidence of calcification or effusion. Enlargement of ascending aorta is 4.3 cm. I am asymptomatic. I use to do exercise daily and have a pretty good diet. I do have minor ischemia. I stopped taking calcium supplements after the angioplasty. I take 400 mg of Magnesium glycinate daily, 5000 IU of vitamin D about 4 times a week and 45 mcg of vitamin K2 daily. I use a transdermal Magnesium chloride spray (EASE) on the chest area daily. I am taking a variety of supplements including Omega 3, vitamin C, CLA, L-Camatine, Ubiquinol, Strontium for my senior osteoporosis, Pycnogenol, Mycophyto (combination of 6 mushrooms and garlic). I am also taking medications which include Plavix 75 mg daily, Verapamil ER 300 mg, Simcor 500/20 mg and Aspirin (enteric coated) 81 mg. I have been told by three cardiologists that calcification is irreversible and probably genetic. My questions are is cardiac calcification an irreversible condition? Does any significant (and accessible) studies prove that? Whether addition of crystallized magnesium chloride is helpful for decalcification process? If so what are the other forms of magnesium can I take along with it? Whether oral chelation (EDTA supplements) is safe and effective in decalcification and recommended doses? Do Aspirin or Plavix block GLA and cause calcification? I am pleased for your recommendation.

Thank you for your thoughtful response doctor,

You mentioned the possibility of some decalcification, irreversibility of the advanced calcification and the possible prevention of further calcification. Based on the previous information and the details I am providing in this follow up, could you please let me know approximately. The percentage of the decalcification I should achieve? How specifically can I bring the reversal? Measures to prevent further calcification. I suppose these are the core questions. I understand the explanation of the undissolved crushed calcium being followed by additional calcium. Currently, I have stopped taking calcium supplements but still I have normal range blood calcium. Should I begin calcium again? How can I apply Dr. Dean's findings to my situation? I am taking 400 mg of Magnesium glycinate daily and also transdermal Magnesium chloride. I am going to start adding the crystallized Calcium chloride once daily. But in your answer you said to take either former or latter. Which is preferable, the glycinate or chloride? If glycinate, is 400 mg sufficient? If chloride, which is better, transdermal or oral? Among the other supplements and medicines I described in original query. Is there anything that could promote calcification? Please ensure whether I am taking sufficient vitamin K2? How do I know I have the correct balance between vitamin K2 and D3? Is vitamin K2intake a significant contributor to decalcification? I read a book about a year ago called "The Calcium Bomb," that characterizes the calcium deposits as nanobacteria. Has this been proven wrong, or is it still a viable theory. Answers to your "Preventive Measures" questions: The Magnesium chloride was discovered accidentally. My sister-in-law has taken this for years. When she heard of my problem, she gave us a bag of crystals, stated on the label that they aid in decalcification of the arteries. The crystals are diluted in water and then taken in 1 oz dose mixed in a 4 oz glass of juice. I tried them and had some constipation issues. That lead us to the transdermal form (EASE), which I have been regularly using, spraying on chest and carotid arteries. EDTA - I had never tried this, but have read about it. I recently heard of a doctor here doing a clinical study on chelation therapy, but he is confining study to those who have already suffered a heart attack. I have always been reluctant to take the EDTA supplements because they are not regulated and I have no idea of the safety and effective dosage. Joints involved in Osteoporosis are Mild osteopenia in left hip (18% increase in density since 2004 - 2% decrease since 2009), Severe osteopenia in right hip (5% increase since 2004 - 3% increase since 2009), Normal lumbar spine (34% increase since 2004 - 10% increase since 2009), Right femoral neck 74% of expected value, T-Value -2.2, Lumbar spine L2 through L4, density 1.233, T-Value -0.1, Left femoral neck density 0.888 g/cm^3- 83% of expected value, T-value -1.4, Lipid profile - cholesterol 137; HDL 65, LDL 56, triglycerides 78. I am non diabetic. I am taking medications (cardiac) Verapamil 300 mg, Simcor 500/20 mg, Plavix 75 mg, Aspirin/enteric coated 81 mg. My BP is in normal range between 120 to 130 mmHg over 70 to 80 mmHg. I take dietary fiber supplements such as Benefiber daily and Align probiotic daily. Normally I drink water of 4 glasses (12 oz) daily along with 4 oz aloe and 4 oz pomegranate juice, about three cups decaf coffee and a glass of red wine with dinner.