Patient's Query
Hello doctor,
I am 26 and was diagnosed with Crohn’s disease one year ago. I have had multiple flares this year with bloody diarrhea, fatigue, and abdominal pain.
My colonoscopy showed patchy ulcers in the terminal ileum, and my CRP is 18. I have been on Azathioprine, but it is not controlling symptoms well.
My doctor wants to start me on a biologic injection like Ustekinumab. How safe is this long-term?
Can I still get pregnant in the future?
Also, I am losing weight fast and feel drained. Can you explain in plain words what Crohn’s is and whether diet plays a role in managing it?
Kindly suggest.
Hello,
Welcome to icliniq.com.
I understand your concern.
Crohn’s is a long-term condition in which your immune system becomes overactive, leading to patchy inflammation and ulcers in the gut (often the terminal ileum).
When the lining is inflamed, it can bleed, cause diarrhea, pain, poor absorption, and weight loss. Diet can reduce symptoms and help with nutrition, but medicines are usually needed to heal the bowel and prevent strictures or fistulas.
If Azathioprine is not controlling flares, moving to a biologic is reasonable. Ustekinumab targets specific immune signals and has been used for years in many patients; the main risks are infections (screen for TB (tuberculosis) or hepatitis, and keep vaccines updated) and rare skin cancers. Overall, it is considered well-tolerated with monitoring.
It does not usually reduce future fertility. Most women with Crohn’s can have normal pregnancies; outcomes are best when the disease is in remission for three to six months before conception.
Many biologics, including Ustekinumab, are commonly continued if needed; active disease is usually riskier than the medication.
For weight loss, focus on the following:
Take high-calorie, high-protein small meals.
Add oral supplements.
Treat iron, B12, and vitamin D deficiencies (if any).
Avoid triggers during flares (very high fiber, greasy foods, or lactose if sensitive).
An IBD (inflammatory bowel disease) dietitian can tailor a plan for you.
I hope you find this helpful.
Thank you.
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Answered byDr. Syed Asif Rafiq
Medically reviewed byiCliniq medical review team
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