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Can ketamine help in treatment‑resistant depression?

This Premium Q&A, reviewed and published, features a real conversation between an iCliniq user and a physician.

Patient's Query

Hi doctor,

I have been struggling with major depressive disorder for years and have tried various treatments without much success. Recently, I read about ketamine being used for treatment-resistant depression, and I am curious to learn more. Please answer the following:

  1. How does ketamine work in treating depression, and what makes it different from traditional antidepressants?
  2. Are there specific criteria to determine if someone is a good candidate for ketamine treatment?
  3. What is the process like, and how quickly can one expect to see results?
  4. Are there any significant side effects or risks associated with ketamine therapy?

Please help.

Thank you.

Answered by Dr. Amit Dhamankar

Education:

MBBS

Professional Bio:

Dr. Amit Dhamankar is a dedicated Intensivist and General Physician with expertise in critical care, emergency medicine, and the management of complex medical conditions. He is skilled in treating acute and chronic illnesses, ICU care, and advanced life support. With a patient-focused approach, Dr. Dhamankar ensures timely diagnosis, evidence-based treatment, and compassionate care to improve patient outcomes and overall health.

This doctor is not available for online consultations on the platform anymore.

Hi,

Welcome to icliniq.com.

I read your query and understand your concern.

Ketamine (a dissociative anesthetic) is used only in resistant cases where all other traditional antidepressants (medicines used to treat clinical depression or prevent it from recurring) have been ineffective. Ketamine has other side effects, like conscious sedation (a depressed level of consciousness during which a patient retains control over his protective reflexes and can respond to commands).

Dissociative anesthesia is when a person might be awake and still be unresponsive. It might also induce bad dreams in some people. So, definitely, Ketamine is the last option in therapy. Also, it has addictive abilities.

I hope that you get your answer.

Please let me know if you need any help.

Thank you.

Medically reviewed by iCliniq medical review team
Published At August 20, 2024
Reviewed At July 21, 2025

Education:

MBBS

Professional Bio:

Dr. Amit Dhamankar is a dedicated Intensivist and General Physician with expertise in critical care, emergency medicine, and the management of complex medical conditions. He is skilled in treating acute and chronic illnesses, ICU care, and advanced life support. With a patient-focused approach, Dr. Dhamankar ensures timely diagnosis, evidence-based treatment, and compassionate care to improve patient outcomes and overall health.

This doctor is not available for online consultations on the platform anymore.

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Education:

MBBS

Professional Bio:

Dr. Amit Dhamankar is a dedicated Intensivist and General Physician with expertise in critical care, emergency medicine, and the management of complex medical conditions. He is skilled in treating acute and chronic illnesses, ICU care, and advanced life support. With a patient-focused approach, Dr. Dhamankar ensures timely diagnosis, evidence-based treatment, and compassionate care to improve patient outcomes and overall health.

This doctor is not available for online consultations on the platform anymore.

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