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Can excess intake of water give false negative drug test?

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Patient's Query

Hi doctor,

I took a drug test and it came out negative, I am on Oxycodone 5 ml, Gabapentin, Methocarbamol and Lisinopril. How could it come out negative while taking these drugs? I drink a lot of water. Is this the cause? How does this happen? Please help.

Answered by Dr. Srivastava Sumit

Education:

MBBS

Professional Bio:

Dr. Sumit Srivastava is a skilled General Practitioner and Family Physician with extensive clinical experience. He is also an expert in Internal Medicine, dedicated to providing comprehensive healthcare for individuals and families. Known for his patient-focused approach, he ensures quality care and long-term wellness. His expertise includes managing lifestyle disorders, chronic illnesses, and preventive healthcare, with a strong emphasis on accurate diagnosis and holistic treatment.

This doctor is not available for online consultations on the platform anymore.

Hi,

Welcome to icliniq.com. Two common potential causes for false negative opiate tests are using the wrong test for a specific opiate or having an insufficient concentration of an opiate in the sample. Other possible reasons can be due to dilution. For example, ingesting a substantial amount of water like you take or you are an ultrafast metabolizer. Urine drug test is widely used for testing Opioids and illicit drugs. There are two types of test, a screening test and a confirmatory test.The screening test uses an immunoassay to look for the parent drug or metabolite. Most screen for Marijuana, Cocaine, Opiates, PCP (Phencyclidine) and Amphetamines, while some also test for Benzodiazepines and Methadone. The confirmatory urine drug test is done by gas chromatography or mass spectrometry (GC/MS) or high-performance liquid chromatography (HPLC). This test is highly specific and is typically used when testing for the presence of a specific drug is needed. The common drugs tested are Amphetamines, Barbiturates,Benzodiazepines, Cannabinoids (THC - tetrahydrocannabinol, Marijuana), Clenbuterol,Cocaine,Codeine, Euphorics (Ecstasy), LSD (Lysergic acid diethylamide), Methamphetamines, Nicotine (Cigarettes), Opiates,Phencyclidine (PCP), Phenobarbital, and Steroids.

Medically reviewed by iCliniq medical review team
Published At March 31, 2016
Reviewed At February 2, 2026

Education:

MBBS

Professional Bio:

Dr. Sumit Srivastava is a skilled General Practitioner and Family Physician with extensive clinical experience. He is also an expert in Internal Medicine, dedicated to providing comprehensive healthcare for individuals and families. Known for his patient-focused approach, he ensures quality care and long-term wellness. His expertise includes managing lifestyle disorders, chronic illnesses, and preventive healthcare, with a strong emphasis on accurate diagnosis and holistic treatment.

This doctor is not available for online consultations on the platform anymore.

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Education:

MBBS

Professional Bio:

Dr. Sumit Srivastava is a skilled General Practitioner and Family Physician with extensive clinical experience. He is also an expert in Internal Medicine, dedicated to providing comprehensive healthcare for individuals and families. Known for his patient-focused approach, he ensures quality care and long-term wellness. His expertise includes managing lifestyle disorders, chronic illnesses, and preventive healthcare, with a strong emphasis on accurate diagnosis and holistic treatment.

This doctor is not available for online consultations on the platform anymore.

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