Q. Can you please go through my electrophoresis report and tell me if I have thalassemia minor?

Answered by
Dr. Goswami Parth Rajendragiri
and medically reviewed by iCliniq medical review team.
This is a premium question & answer published on Mar 17, 2017 and last reviewed on: Oct 09, 2018

Hi doctor,

Could you please go through my reports and tell me if I have thalassemia minor? I have attached my electrophoresis test reports. Some of the values in the report are Hb F - 0.8 %, Hb adult - 66.0 %, Hb A2 - 30.8 % and other non-specific - 2.4 %.



Welcome to

  • According to the report attached (attachment removed to protect patient identity), the Mentzer index is not below 13. Usually, in thalassemia, it is below 13.
  • Hb A2 (hemoglobin A2) level is raised, which is seen in beta thalassemia minor as well as in hemoglobin E hemoglobinopathy.
  • HPLC (high-performance liquid chromatography) is confirmatory for diagnosing various hemoglobinopathy.
  • So, thalassemia is not present. But, blood transfusion history should be ruled out. Also, a correlation with clinical finding and preliminary symptoms should be done.

Revert with more information to a hematologist online -->

Hi doctor,

Thanks for taking out time to check the report. No, there was no history of blood transfusion. So, I am not a beta-thalassemia carrier, right?



Welcome back to

I will try to explain your report.

  • In HPLC test, different hemoglobins are eluted at a different time and accordingly the report is given. Hemoglobin A2 and E are eluted at the same point.
  • Hence, your diagnosis is given after considering HPLC, MCV (mean corpuscular value) and RBC (red blood cell) mass, from which Mentzer index can be calculated which is not here below 13.
  • So your diagnosis is hemoglobin E hemoglobinopathy. But as you are heterozygous, your partner's HPLC should also be done, and pre-conceptional counseling is advised.

For further queries consult a hematologist online -->

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