Ena Panel

An extractable nuclear antigen (ENA) panel is a blood test that detects autoantibodies in the blood that react with proteins in the cell nucleus. ENA panel typically consists of a group of four or six autoantibody tests. ENA panel testing is used to distinguish and monitor different autoimmune disease progression. In addition, it may be used as follow-up testing to a positive antinuclear antibody (ANA) test to help diagnose an autoimmune disorder.

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Previously positive ANA turned negative. Is it safe to plan pregnancy now?

Query: Hello doctor,My daughter had a little girl four years ago. About three months postpartum, she fell down a flight of stairs injuring her back. At the same time, she had a very bad cold. When her back continued to give her pain after seeing the orthopedist, she went to a neurologist. Her blood work sh...  Read Full »


Dr. Naval Mendiratta

Answer: Hello, Welcome to icliniq.com. Yes, there have been cases where ANA once positive becomes negative towards the later part. Initially, it may have been induced by pregnancy or any infection but over course of time, it becomes negative. As for your friend, I would suggest we do ENA (extractable nucl...  Read Full »

What does severe fatigue with positive ANA test indicate?

Query: Hello doctor, In January, I started to become very fatigued. My doctor sent me for some lab works and my ANA tested positive when a high membrane pattern of 1:1280. I have pain in my hands and back of my legs and the fatigue has continued since then. I also developed a bumpy rash on my abdomen. I ...  Read Full »


Dr. Divya Agarwal

Answer: Hi, Welcome to icliniq.com. Your test suggests that you are suffering from a connective tissue disease. The symptoms may be nonspecific like you have fatigue, arthritis, rash, dry eyes, and mouth. It is advisable to do an extractable nuclear antigen (ENA) to reveal which particular antibodies ar...  Read Full »

Why do I have pain in my hands and wrists?

Query: Hi doctor, I am having pain in my hands and wrist and it started a few months ago. It is typically in the morning. I visited a doctor and she did blood tests. The result flagged in my blood tests was anti-Sm/RNP 2.8 and she has referred me to a rheumatologist, who cannot see me for the next two ...  Read Full »


Dr. Naval Mendiratta

Answer: Hi, Welcome to icliniq.com. Well, the antibody as such does not match your symptoms. It is an antibody for autoimmune disease more like SLE (systemic lupus erythematosus). Since it is positive, I would like to know if your ANA (antinuclear antibody) was positive as well, or only this came positive. ...  Read Full »

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