Does Valproate affect the liver or blood in epileptic patients?

Question

Hello doctor,

I’m 24 and was diagnosed with epilepsy two years ago. My brain test showed a certain pattern, and I have been taking Valproate twice a day. I have not had any seizures in a year. However, my recent blood tests showed low platelets and slightly elevated liver enzymes. Should I be worried that the medicine is affecting my liver or blood cells? Would switching to another medication be better in the long term? Also, do I need to keep repeating brain scans or tests if I am doing well? What else can I do to prevent future attacks? Are there any lifestyle changes I should adopt after discontinuing the medication?

Kindly advise.

Answer 1

Hello,

Welcome to icliniq.com.

I understand your concern.

I understand that not knowing much about seizures and epilepsy can be really worrying.

Basically, a seizure is caused by abnormal electrical activity in the brain cells, which are called neurons. There can be multiple triggers for a seizure episode, such as high-grade fever, certain viral or bacterial infections, low blood sugar (hypoglycemia), low blood pressure, or a family history of seizures. Other common triggers include lack of sleep or rest, hyperactivity, alcohol abuse, and drug use.

Even a single episode of seizure can be followed by another and usually requires long-term treatment, typically a minimum of three years. If another seizure occurs during treatment, the duration of treatment may be extended further.

It is also important to avoid activities like driving or swimming alone, as a seizure can happen unexpectedly. It is safer to have someone nearby in such situations.

Yes, Valproate can cause elevated liver enzymes, which is why liver function tests (LFTs) should be monitored, especially during the first six months of treatment.

You generally do not need to repeat brain scans if the type of seizure has already been diagnosed. Also, it is best not to switch medications without the advice and supervision of your treating physician.

As for lifestyle changes, it is important to avoid known triggers like stress, get regular moderate exercise, eat a healthy diet, maintain a consistent sleep schedule, and avoid alcohol and recreational drug use.

I hope you are satisfied with my answer. For further queries, you can consult me at iCliniq.

Thank you.