Patient's Query
Hello doctor,
I have found this service to be incredibly helpful, and I have received some bloodwork back that I would like to better understand.
I am a 24-year-old male, 6 feet tall, weighing 188 pounds, and I began experiencing frequent urination about three months ago. Although I do not have a family history of it, I became concerned about the possibility of diabetes due to the symptoms. During that same time frame, I was also the most stressed I have ever been. It was my final exam, and I decided to get married during all of that. As a result, I was more sedentary than usual and also eating a diet that mainly consisted of frozen pizzas and takeout. As someone who has always been fairly lean and lifts weights four to five days per week, I perhaps stupidly thought I could eat whatever I wanted. With these new test results, which I will enumerate below. I would first like to know if it is possible to develop insulin resistance in the liver even at a healthy, lean body weight, and second, I would like to know the steps I need to take now to reverse it.
My latest blood test also has slightly abnormal BUN (blood urea nitrogen) or creatinine levels, so I would appreciate any insights on that, although I have been drinking too many protein shakes lately, so I wonder if that has acutely affected it. So my two primary questions are the following:
The diet advice I can find online seems a bit contradictory since most places say low-fat protein and complex carbs are good for cholesterol, but diets for insulin resistance say to eat mostly fats and proteins, but no carbs. I really appreciate any clarification on that.
Kindly help.
Thank you.
Hi,
We welcome you to icliniq family.
I appreciate the confidence you place in me for your healthcare consultation.
Yes, the unhealthy diet, stress, and sedentary lifestyle in the recent past may have contributed to the changes you have noticed. Yes, it is possible to develop insulin resistance at any body weight. Body weight or BMI (body mass index) are not a foolproof way to measure normal fat mass.
You already know the answer. Eat more vegetables and stop consuming frozen pizzas and takeouts. Get back to the gym and restart lifting. Also, include cardio. Have the goal of adding more veggies to the diet, plant-based protein and whole grains. Do not be confused by the macronutrient composition, except for increasing the fiber in the diet.
I hope this has helped you. Please feel free to reach out to me again in case of further queries.
Do follow up whenever needed.
Let me know if I can assist you further.
Thank you.
Patient's Query
Hi doctor,
Thank you for the reply.
For my own understanding of the causal factors here, does a plausible chain of events look like my bad diet and lack of exercise led to poor cholesterol, reflected in the elevated LDL (low-density lipoprotein), and that in turn began to cause some insulin resistance issues that have driven the blood sugar levels and symptoms reflected in the frequent urination and higher-than-healthy HbA1C (glycated hemoglobin) levels?
I primarily ask because I would like to know if targeting the LDL levels with dietary changes and more exercise will, as a result, lead to a mitigation of the urinary and blood sugar-related symptoms.
I would certainly like to continue to eat carbs (healthy ones, of course) and reduce my fat intake to improve cholesterol, rather than cut out carbs to target the blood sugar issues.
Kindly help.
Thank you.
Hi,
Welcome back to icliniq.com.
No, it need not follow a chain of events, as I have mentioned. The LDL cholesterol did not necessarily lead to insulin resistance; it may be the vice versa or both occurring concurrently. The frequent urination is not something I would anticipate at the FBG and HbA1c levels. Dietary fat content does not directly convert into LDL.
In the background of insulin resistance, any excess energy in the form of excess calories (either from carbs or fat) will be stored as triglycerides in the adipose tissue and liver. This, in turn, alters the liver's normal handling of lipoproteins such as LDL and increases LDL cholesterol. The common pathway for high glucose and increased cholesterol levels is more carb intake rather than more fat, so cutting down on both carbs and fat is needed. I always recommend cutting down on carbs more. I am not sure if I have made myself clear. That is why I do not want to get into this macronutrient debate, carbohydrate versus fat. Simply cut down on excess calories, be it carbs or fat, and avoid processed food. Increase fiber intake, which will provide satiation (so you eat less carb and fat), increase satiety, and reduce absorption of fat.
Do follow up whenever needed.
Let me know if I can assist you further.
Thank you.
Patient's Query
Hi doctor,
Thank you for the reply.
More vegetables, more fiber, and leaner proteins are in order and well overdue. Along with getting back to a more active regimen that includes not just weights but also cardio exercise.
To provide a more direct inquiry: Taken together, and not considering causation or any sort of dependent relationships, does my LDL, along with the A1C and FBG, which are both technically normal but on the higher end, suggest a mild form of insulin resistance? I noticed that my C-peptide result was on the lower end of normal as well.
I have had several urinalyses done that have not detected anything in the urine, so the frequency and urgency of it has become quite a hindrance to my daily life. I understand if you would prefer not to speculate, but can you provide any other potential causes behind that frequent urination when taken with my test results? You have been very clear on the nutrition discussion above, and I appreciate you taking the time to explain it to me.
Kindly help.
Thank you.
Hi,
Welcome back to icliniq.com.
C-peptide measures insulin-secreting capacity. Insulin measures insulin sensitivity or resistance. Both should be interpreted based on what the glucose was at the same time. Since your glucose was 95 mg/dL when C-peptide was measured, it is normal. I would rather measure fasting glucose and insulin at the same time to assess your insulin sensitivity or resistance. The test results, including the urine tests, do not have an explanation for the urinary urgency and frequency. Does it wake you up at night? Do you take any supplements that might cause these symptoms? If the symptoms continue, you should consider visiting a urologist.
Hope I have solved your query. I will be happy to help you further.
Thank you.
Patient's Query
Hi doctor,
Thank you for the reply.
At the time of my blood glucose test, I had been fasting for 12 hours. So both my glucose and C Peptide numbers were in a fasted state. Does that add anything to your consideration? Regarding waking up at night, I have consistently been waking up once per night, but sometimes twice. The supplements angle is one I have considered. In the past few months, I have experimented with all sorts of herbs, vitamins, and minerals in an attempt to better deal with stress from school and work. I have been thinking it best to stop taking them all to see if that has any effect
Hi,
Welcome back to icliniq.com.
12 hours of fasting before the test is reasonable. If urinary frequency or urgency is waking you up at night, try limiting fluid intake after dinner time. I do not know off the top of my head of any supplements that could cause these symptoms, but it is worth a shot to stop one or a few at a time to see if it would improve your symptoms.
Hope I have solved your query. I will be happy to help you further.
Thank you.
Same symptoms don't mean you have the same problem. Consult a doctor now!
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