My neutrophils and immature granulocytes are increased after an MVA. Why?

Question

Hi doctor,

I had a CBC with results after a highway speed MVA showing high neutrophils (8.03 k/uL and 77.5%) and high immature Grans Abs (0.06 k/uL and 0.6%). Everything else fell within the normal range. Everything I am reading online is scaring the crap out of me. I am under Trazodone, Fluoxetine, Buspirone, Gabapentin and Methocarbamol. I do not have any current complaints. I have a primary doctor's appointment next week. Is there anything that my doctor should be doing to follow up on it? What should I ask my doctor during my visit?

Kindly give your opinion.

Answer 1

Hi,

Welcome to icliniq.com.

I went through all of your data. Although your results are out of reference ranges, they are not out of clinical ranges. Clinical range means all of your differential diagnoses seem normal. Neutrophils are increased in stress, acute infections, inflammations, steroid use, fever, leukemias, pregnancy, etc.

Please rule out the causes. For an evaluation, get CRP (C-reactive protein) and ESR (erythrocyte sedimentation rate) tests done and send them to us.

The word "leukemia" means white blood cell cancer in peripheral blood. Leukemia is a relatively old term. Nowadays, it is called hematopoietic and lymphoid neoplasm. A good share of circulating white cells comes from lymphoid tissues such as lymph nodes, spleen, thymus, etc. And the rest of the cells come from bone marrow. Lymphoid tissue is present all over the body, even in the intestine, lungs, liver, etc. The neoplasms of lymphocytes, white blood cells, are called lymphomas, which are rarely present in the blood.

They are present in lymphoid tissue. However, they do infiltrate blood and bone marrow at some later stages (stage 4 disease). Now, there are certain neoplasms arising from bone marrow. They are myeloid or lymphoid leukemias. They are most of the time present in peripheral blood. In addition, leukemia and lymphoma are not merely the presence of certain types of abnormal cells.

It is a whole package comprising anemia, leukopenia or leukocytosis, high ESR, thrombocytopenia, unexplained fever, weight loss, arthralgias, myalgias, etc. These are diagnosed using FNAC (fine needle aspiration cytology), bone marrow biopsy, immunohistochemistry, flow cytometry, radiological surveying, etc. These are treated with chemotherapies selected according to the type of cells involved in lesions.

I hope this was helpful.