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I’m a male starting transition. What medicines do I need?

This Premium Q&A, reviewed and published, features a real conversation between an iCliniq user and a physician.

Patient's Query

Hello doctor,

I am a male undergoing gender transition and would like to inquire about taking female hormone therapy. Could you please advise me on the appropriate medications and steps involved?

Kindly suggest.

Hello,

Welcome to icliniq.com.

I understand your concern.

Thank you for your question. If you are beginning a gender transition and are considering feminizing hormone therapy (also known as hormone replacement therapy or HRT), it is essential to do so under the care of a qualified healthcare provider, ideally an endocrinologist with experience in transgender care.

Medical supervision ensures safety, appropriate dosing, and effective progress toward your transition goals. Feminizing hormone therapy typically includes estrogen, which promotes the development of female secondary sexual characteristics, and anti-androgens, which reduce testosterone levels.

Estrogen can be administered in several forms:

  • Oral tablets.

  • Skin patches.

  • Injections.

  • Topical gels.

Common anti-androgens include Spironolactone, Cyproterone acetate (available in some countries), and Gonadotropin-releasing hormone agonists, which reduce testosterone production more directly.

The choice of medications and dosages depends on your health profile, goals, and laboratory results. Before starting hormone therapy, the following baseline tests are typically recommended:

  • Liver and kidney function tests.

  • Blood sugar and lipid profile.

  • Hormone levels (testosterone, estrogen, LH (luteinizing hormone), FSH (follicle-stimulating hormone).

  • Prolactin level.

Regular follow-up every three to six months is essential to monitor hormone levels, adjust doses if needed, and check for side effects. This ongoing care helps reduce risks and ensures your therapy is safe and effective.

Self-medicating without medical guidance can lead to serious complications, including blood clots, liver damage, or hormone imbalances.

For your safety and long-term well-being, working closely with a healthcare provider is strongly recommended. A guided approach offers the best path forward on your transition journey.

I hope this information helps you.

Thank you.

Medically reviewed byiCliniq medical review team

Published At October 15, 2025
Reviewed AtOctober 22, 2025

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