Which is better for controlling eye pressure, Dorzolamide or Brimonidine?

Q. Is it necessary to use four eye drops to control eye pressure?

Answered by
Dr. Shikha Gupta
and medically reviewed by iCliniq medical review team.
This is a premium question & answer published on Sep 29, 2016 and last reviewed on: Jul 03, 2023

Hi doctor,

Four eye drops are used in combination to control eye pressure in case of glaucoma. They are Dorzolamide, Timolol, Brimonidine and Xalatan. In what sequence with how much gap should they be given to control eye pressure? Also for controlling afternoon pressure, either Dorzolamide or Brimonidine, which is better? Should I give Dorzolamide three times or Brimonidine three times?



Welcome to icliniq.com.

It is necessary to use more than one drop when intraocular pressure is not controlled by a single drug. Every drug you mentioned has a different mechanism of action. It is good till IOP is controlled with medical management. Each drug is having different mechanism and one drug does not interact or interfere with others mode of action or effect. Time of day for better efficacy is not proved for all drugs. It is good to use Xalatan (Latanoprost) at night before sleep. The rest of them you have to use two times a day. You can use Timolol first, followed by Brimonidine with a gap of at least 10 minutes. Then, followed by Dorzolamide again with a gap of 10 minutes. Do not use them three times. Use Dorzolamide and Brinzolamide only two times. For evening pressure, do eye massage or rubbing with palm light-handedly after washing with clean water. Other medicines have to be followed as such.

Was this answer helpful?


Same symptoms doesn’t mean you have the same problem. Consult a doctor now!

Related Questions:
Can glaucoma and cataract be operated at the same time?

.. all reports carefully (attachment removed to protect patient identity). Your doctor has correctly said that it is an advanced form of glaucoma. The treatment depends on the type of glaucoma, either open-angle glaucoma or closed angle glaucoma.   Read full

Why have my blemishes not improved even after extended use of Roaccutane?

.. your clinical picture (attachment removed to protect patient identity). It is looking like acne cyst for me. The probable diagnosis is acne grade 4 with scars Is the blemish raised and painful? Can you feel that with your finger or is it just flat re   Read full

Diagnosed with Glaucoma: What Next?

.. condition that is caused by fluid-build up and increased pressure in the eye, leading to progressive vision loss .. ...   Read full

Also Read Answers From:

ideaComprehensive Medical Second Opinion.Submit your Case

Also Read

PCOS and Liver Problems
The hormonal imbalances in polycystic ovary syndrome could cause liver diseases. Read the article to know the relationship between these medical conditions.  Read more»
Inferior Alveolar Nerve Lateralization Technique
The inferior alveolar nerve lateralization technique is a surgical lateralization technique to reposition the nerve. Read the article to know more about this.  Read more»
COVID-19 and Ebola: Similarities and Differences
This article gives a comparison and broader overview of the outbreak of the two deadliest diseases that showed a greater incidence over the last two decades.  Read more»

Ask your health query to a doctor online?

Ask an Eye Care Ophthalmologist Now

* guaranteed answer within 4 hours.

Disclaimer: No content published on this website is intended to be a substitute for professional medical diagnosis, advice or treatment by a trained physician. Seek advice from your physician or other qualified healthcare providers with questions you may have regarding your symptoms and medical condition for a complete medical diagnosis. Do not delay or disregard seeking professional medical advice because of something you have read on this website. Read our Editorial Process to know how we create content for health articles and queries.