How does Ketamine help in the management of pain?

Question

Hello doctor,

I am a 37-year-old male. May I know some information about Ketamine? What role does ketamine play in chronic pain management? How does Ketamine help in the management of depression and anxiety? Are there potential side effects or contraindications that I need to be aware of?

Thank you.

Answer 1

Hello,

Welcome to icliniq.com.

Ketamine is a medication primarily used for anesthesia and pain management. In chronic pain management, ketamine can be administered via various routes, including intravenous infusion or oral or topical formulations, to alleviate neuropathic pain and central sensitization. In the treatment of depression and anxiety, ketamine has gained attention for its rapid-acting antidepressant effects.

It works by blocking NMDA (N-methyl-D-aspartate) receptors and enhancing synaptic plasticity in the brain. Ketamine infusion therapy has shown promising results, particularly for treatment-resistant depression and acute suicidal ideation. However, it is essential to be aware of potential side effects and contraindications, including dissociation, hallucinations, increased blood pressure, and risk of dependence or misuse. Ketamine should be administered under medical supervision, and its use requires careful monitoring, especially in individuals with a history of substance abuse or certain medical conditions.

I hope this answers your questions.

Thank you.