Q. I got swollen and painful lump in my armpit post influenza vaccination. Why?

Answered by
Dr. Thakre Mahendra Shivram
and medically reviewed by Dr. Vinodhini. J
This is a premium question & answer published on May 06, 2020 and last reviewed on: May 16, 2020

Hello doctor,

I got the influenza vaccination about a week ago and have a swollen and painful lump in my armpit.



Welcome to

I understand your concern. You are having lymph node swelling axillary post influenza vaccination. Influenza vaccine is a very safe vaccine. Although some may have local pain, swelling, and fever. Some may have local lymphadenopathy.

Lymphadenopathy is a swelling of lymph node (normal gland present in our body, which function as clearing harmful substances and providing immunity). Local and systemic reactions mostly began between day 1 and day 2.

When a lymph node rapidly increases in size, its capsule stretches and causes pain. Pain is usually the result of an inflammatory process. It is a reactive response of the lymph node to the vaccination. So no need to worry.

It can be managed by simple Paracetamol or anti-inflammatory medication such as Serratiopeptidase. It should resolve within a week. If it is associated with fever or any other site enlargement of lymph node you can visit your physician.

I hope this helps.

The Probable causes:

Reactive lymphadenitis.

Investigations to be done:

CBC (complete blood count), ESR (erythrocyte sedimentation rate), USG (ultrasound) axillary lymph node.

Differential diagnosis:


Treatment plan:

anti-inflammatory Paracetamol 500 mg twice or thrice daily or Aceclofenac, Paracetamol, and Serratiopeptidase combination tablet twice daily for three days.

Regarding follow up:

Follow up after three days.

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