What are the clinical trials for ROS1-mutation lung cancer?

Question

Hello doctor,

My grandfather is 71 years old and has been diagnosed with lung cancer carrying a ROS1 mutation. His current treatment does not seem to be working as expected, and we are desperately looking for other options.

What clinical trials exist for a 71-year-old with ROS1 mutation lung cancer?
Are there any eligibility restrictions based on his age or other health conditions?

We want to explore every possible avenue before it is too late. Please guide us on how to find and enroll in relevant trials as soon as possible.

Please help.

Thank you.

Answer 1

Hello,

Welcome to icliniq.com.

I have gone through your query and understand your concern.

I wish you good health and a speedy recovery for your grandfather. I understand and appreciate the amount of fear and concern you have.

I want to explain an important point. Lung cancer treatment depends on many factors that help us choose the best treatment modality. These include the stage of the disease, the type of cancer cells, whether they are small-cell or non-small-cell lung cancer, and the genomic and mutation test results.

We do not test only ROS1 (protooncogene receptor 1 receptor tyrosine kinase); we usually perform more than twenty genomic tests. The patient's general condition, age, and any other comorbidities also influence treatment decisions.

Regarding the medication he is currently taking, it is likely a targeted therapy, and there are many types of targeted therapy. We can switch from one type to another if needed. We can also consider immunotherapy, which can provide strong tumor control and suppression with minimal side effects. Many patients tolerate it well and may live on it for more than ten years.

Please do not forget to give him full emotional and nutritional support.

I hope I have answered your question.

Let me know if I can assist you further.

Thank you.