Do people with lupus nephritis eventually require dialysis?

Question

Hello doctor,

I have been living with systemic lupus erythematosus (SLE) for about eight years, and recently my urinalysis showed a significant increase in proteinuria (protein in the urine). I have also been feeling extremely fatigued and have noticed swelling (edema) in my face and ankles. My nephrologist mentioned that this could indicate a worsening of lupus nephritis (kidney inflammation caused by lupus), and now my serum creatinine levels are gradually rising as well.

I am currently taking immunosuppressive medications and low-dose corticosteroids, but I am worried that this could be progressing toward kidney failure. Is there anything more I can do to slow or stop the progression of lupus nephritis? Do many people with this condition eventually require dialysis?

Please help.

Answer 1

Hello,

Welcome to icliniq.com.

I understand your concern.

The primary goals of treatment for lupus nephritis are to reduce symptoms and achieve remission, prevent the disease from worsening, and avoid the recurrence of symptoms. Additionally, it is crucial to preserve kidney function to prevent the need for dialysis, a process that filters waste from the blood, or a kidney transplant. Medications commonly used to treat lupus nephritis include corticosteroids like Prednisone, immunosuppressive drugs such as Cyclosporine, Voclosporin, Tacrolimus, Cyclophosphamide, Azathioprine, Mycophenolate, Rituximab, and Belimumab.

Unfortunately, kidney failure can occur in about 30 percent of individuals with lupus nephritis within 15 years of diagnosis, at which point dialysis or a kidney transplant may be necessary. Your current treatment plan likely involves immunosuppressants and steroids to manage the condition and slow its progression.

I hope you are satisfied with my answer. For further queries, you can consult me at iCliniq.

Thank you.