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How to manage and prevent menstrual migraine?

This Premium Q&A, reviewed and published, features a real conversation between an iCliniq user and a physician.

Patient's Query

Hello doctor,

I am 33 years old and suffer from terrible migraines, especially just before my period. Over‑the‑counter painkillers do not help much, and I have missed work frequently. I have heard that hormonal changes in women can worsen migraines.

  1. What are the best treatments for that?
  2. Are there safe monthly or injection‑based options to prevent attacks?

Kindly help.

Hello,

Welcome to icliniq.com.

I read your query and understood your concern.

Your migraines are menstrual-related, as many women experience a significant worsening of symptoms in the days leading up to their period due to hormonal fluctuations, especially the drop in estrogen. These hormone‑triggered migraines tend to be more severe, longer-lasting, and less responsive to over‑the‑counter painkillers, which seems to be the case for you.

Preventive treatment is often necessary when migraines are frequent or disabling, like yours. Several options can help reduce or prevent these attacks:

  1. Short‑term preventive medications: Some women benefit from taking triptans for a few days around the start of their period for predictable menstrual migraines.

  2. Continuous preventive therapy: Daily medications may include: Beta blockers, certain antidepressants, and anti‑seizure drugs.

  3. Monthly injection‑based treatments: If migraines occur more than four times per month or significantly impact quality of life, options include CGRP (calcitonin gene-related peptide) monoclonal antibodies such as Erenumab, Fremanezumab, or Galcanezumab. These are generally well-tolerated and can be very effective.

  4. Hormonal options: Estrogen patches or contraceptives may be considered carefully if your migraines are closely tied to your cycle. These must be used cautiously and are not recommended if you experience migraines with aura due to increased stroke risk.

I suggest you consult a specialist, talk to them, and take the medications with their consent.

I hope that this answers your query.

Please follow up if you have any further questions.

Answered byDr. Ashraf Ghani

Medically reviewed byiCliniq medical review team

Published At October 16, 2025
Reviewed AtOctober 17, 2025

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