Multiple Myeloma

Multiple myeloma, alias Kahler's disease, is a type of blood cancer that affects the plasma cells. The signs and symptoms of multiple myeloma include bone pain, loss of appetite, frequent infections, weight loss, and weakness in the legs. The exact cause of multiple myeloma is not known.

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Does my CBC history and family history of multiple myeloma indicate I am at risk?

Query: Hello doctor,I am 44 years old male. I am attaching pictures of my seven-year CBC history. Here is what happened this year. On my annual physical examination 11 months back, my WBC was low. Three months back, my GP checked it again. WBC came back in range but platelets were low. Over seven years, pl...  Read Full »

Dr. Goswami Parth Rajendragiri

Answer: Hello, Welcome to Your CBC does not suggest multiple myeloma (attachment removed to protect patient identity). In the case of multiple myeloma, anemia can be there and clinical symptoms like a constant headache, kidney system related symptoms, etc., can be present. But as your father ...  Read Full »

Will allogeneic transplantation help multiple myeloma?

Query: Hi doctor, Recently, my mother is diagnosed with multiple myeloma. She had a fast progression. Within a year, the plasmacytoma progressed to MGUS which resulted in multiple myeloma with severe bone involvement. She got a heart attack at the onset of multiple myeloma. I know that deletion of 17p and ...  Read Full »

Dr. Singh Smrita

Answer: Hi,Welcome to advantage of allogeneic stem cell transplant is that the donor stem cells make their immune cells. They help to destroy the cancer cells that remain after high-dose treatment. It is called a graft-versus-cancer effect. Autologous stem cell transplant does not offer the ...  Read Full »

My mother had multiple myeloma and now has a low serum albumin level. Is it serious?

Query: Hello doctor, Just to let you know, my mother was diagnosed with MM nine years ago. Then she went into remission with Lenalid, Bortezomib, and Dex within three months. Five years ago, her disease came back, and then again took Lenalid, Bortezomib, and Dex. Currently, she is only having Lenalid 10 mg...  Read Full »

Dr. Goswami Parth Rajendragiri

Answer: Welcome to I understand your concern. Your mother's attached report (attachment is hidden to protect the patient's identity) shows a low hemoglobin level and low albumin. You have already mentioned that she has relapsed from cancer and was put on the chemotherapeutic drug again. If yo...  Read Full »

My 73-year-old uncle, who has multiple myeloma, suffers from kidney failure. Please help.

Query: Hi doctor, My uncle, 73 years old was suffering from multiple myeloma. As a result, he had problems with Opioid-induced bowel dysfunction. And also, he had recently undergone surgery regarding resection in the small intestine and being on a ventilator. So now he has renal failure. Both kidneys were ...  Read Full »

Dr. Anshul Varshney

Answer: Hi, Welcome to I can understand your concern. I have gone through your reports (attachment removed to protect the patient's identity). He has an acute or chronic infection. The swelling over the body happens as a result of the following: 1. Fluid retention. 2. Anemia. 3. Protein de...  Read Full »

I have elevated WBC count, CRP, muscle wasting, leg swelling, DM, gastritis, and myeloma. Which test should I take now?

Query: Hi doctor,I have a high WBC count, elevated CRP level, muscle wasting, leg swelling, DM, gastritis, and myeloma, which was normal two years back. Now again, I have to go for a myeloma test or protein electrophoresis, or immunofixation. Please guide me.  Read Full »

Dr. Goswami Parth Rajendragiri

Answer: Hello, Welcome to For gastritis, a Rabeprazole-like drug can be prescribed. But as per mentioned history, globulin is elevated, and your kappa to lambda ratio is high. So it is better to investigate further to rule out plasma cell dyscrasias. For that, investigations like immunofixati...  Read Full »

Does my blood reports and symptoms of hip and abdominal pain indicate anything serious?

Query: Hi doctor, I have been experiencing symptoms like nausea and vomiting over the past year, and it has been progressively getting more frequent. I have had persistent, sometimes debilitating, pain in my hip area for the last few months. X-ray and scans so far have revealed nothing. I am often very fat...  Read Full »

Dr. Goswami Parth Rajendragiri

Answer: Hello, Welcome to I read your query and can understand your concern. Following is my opinion for your reports and asked questions- 1. IgA (immunoglobulin A) and protein values are increased, but electrophoresis is normal. So, some form of inflammation might be responsible for elevat...  Read Full »

I have chest cold with weight loss, nausea, and dry heaves. Is it multiple myeloma?

Query: Hi doctor, My symptoms include a chest cold for approximately one month, 12 pound weight loss, nausea, dry heaves. Excessive bowel movements. Shortness of breath. Muscle aches. Left side rib pain. Fatigue. I had normal labs except mildly elevated alkaline phosphate. My doctor is now running a ALP i...  Read Full »

Dr. Arvind Guru

Answer: Hi, Welcome to After reviewing your complaints and your blood investigation (attachment removed to protect patient identity), I can draw the following conclusions: 1. It is highly unlikely that you have multiple myeloma, as your globulins (in blood report) are normal. Though it is a...  Read Full »

What is the reason for the fluctuations in the protein levels in my blood?

Query: Hi doctor, I have been worrying that I have multiple myeloma, and I cannot stop crying. I am only 27 years old. I have had on and off elevated total protein for the past eight years. Protein was fine before six to seven years, then elevated again. The highest I have seen was the 9.0 range, but it fl...  Read Full »

Dr. Goswami Parth Rajendragiri

Answer: Hello, Welcome to The following is my opinion on your question: The globulin level is high in the attached report (attachments removed to protect the patient's identity). But elevated protein does not always mean multiple myeloma. It could be due to temporary inflammation as well. Yo...  Read Full »

My grandmother has a platelet count of 10,000. Will she be alright?

Query: Hello doctor,My grandmother has a platelet count of 10,000. She is currently on her blood pressure medication. Of note, at the age of 52, she was operated on for severe menstrual bleeding. However, there is no sign of cancer in our whole family. Today is her transfusion. Will she be alright? I have ...  Read Full »

Dr. Singh Smrita

Answer: Hello, Welcome to I have viewed the reports attached (attachment removed to protect patient identity) apart from a punched-out lesion on the skull. There seems to be no abnormality. Generally, a lytic lesion in the bones of an elderly person would raise the suspicion of multiple myel...  Read Full »

How to find the stage of multiple myeloma?

Query: Hi doctor,My 97-year-old mother, who is in a nursing home, is more tired and feeling unwell. A blood test has shown she has likely got multiple myeloma. She had left-sided paralysis from a stroke six years ago. She cannot speak, and she is slow in understanding and writing, but she has no dementia. ...  Read Full »

Dr. Goswami Parth Rajendragiri

Answer: Hi, Welcome to Sorry to hear about your mother's condition. I have read all the test values that you have mentioned. From which, I can see that her total protein is high and albumin is low with elevated gamma globulin. Immunofixation electrophoresis is the best test to detect p...  Read Full »

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