Patient's Query
Hi doctor,
I am a 40-year-old woman struggling with obesity despite diet and exercise. My BMI is 34.2, HbA1c is 5.8 %, and TSH is within the normal range. I was considering injectable weight loss drugs like Semaglutide, but worried about nausea and long-term safety. Could you explain how these drugs work and whether they are suitable for someone with a family history of thyroid disease?
Please advise.
Hi,
Welcome to icliniq.com.
I understand how frustrating it can be to struggle with weight despite a consistent diet and exercise, and it is commendable that you are seeking safe and effective options.
Injectable weight loss medications like Semaglutide belong to a class called GLP-1 (glucagon-like peptide) receptor agonists. These medications work by mimicking a naturally occurring hormone that helps regulate appetite and blood sugar levels, which can lead to feeling fuller sooner and reducing calorie intake.
Many individuals experience significant weight loss over several months with these medications, but common side effects include nausea, vomiting, and sometimes diarrhea, particularly when first starting or increasing the dose.
These side effects often improve over time, though they can be bothersome initially. In terms of long-term safety, current studies indicate that GLP-1 agonists are generally safe for most adults. However, there is a theoretical concern for individuals with a personal or family history of certain thyroid cancers.
Since you mentioned having a family history of thyroid disease, it is crucial to discuss this in detail with your healthcare provider before starting therapy. They may want to monitor your thyroid more closely or consider alternative options.
Overall, these medications can be effective, but the decision should be personalized, weighing the benefits, potential side effects, and your medical history.
I hope this explanation is clear and helpful. Please feel free to ask any questions at any time; we are always here to support you.
Thank you.
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Answered byDr. Ashraf Ghani
Medically reviewed byiCliniq medical review team
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