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Does compounded Semaglutide cause nausea and low appetite?

This Premium Q&A, reviewed and published, features a real conversation between an iCliniq user and a physician.

Patient's Query

Hello doctor,

I am 45 years old and have struggled with my weight for years. A few months ago, my doctor prescribed compounded Semaglutide, and I was able to lose 8.8 pounds, which was the first real progress I had seen in a long time. However, I have now plateaued at this weight and am no longer losing.

Lately, I have also been feeling off, experiencing occasional nausea and sometimes a complete lack of appetite. I am unsure if these symptoms are due to the medication or something else.

I have read that compounded Semaglutide may differ from the standard version, and now I am concerned about whether I am using the right formulation. Should I increase my dose, or is it safe to continue with the current dose long-term?

Please help.

Thank you.

Hello,

Welcome to icliniq.com.

I have read your query and can understand your concern.

To better understand your situation and offer more tailored advice, I need some additional details about your clinical history:

  1. Comorbid conditions: Do you have any underlying health conditions (for example., diabetes, hypertension, thyroid disorders)?

  2. Medications: Are you taking any other medications that could interact with Semaglutide?

  3. Laboratory reports: Could you share your most recent blood work and lipid profile results?

  4. Body mass index (BMI): What is your current BMI?

  5. Diet and exercise: Can you provide more details about your typical diet and exercise routine?

Addressing your concerns:

Weight loss variability:

  1. Individual response: Weight loss with Semaglutide can vary widely between individuals, even with consistent adherence to diet and treatment.

  2. Factors affecting weight loss: Hormonal levels, starting weight, body composition, and overall health status can all influence how well the medication works.

Side effects:

  1. Common side effects: Nausea, dizziness, and headaches are common, especially during dose escalation.

  2. Dose adjustment: If the side effects are bothersome or persistent, we may consider adjusting your dose or slowing down the dose increase.

Once I have this additional information, I can provide more specific guidance on managing your treatment effectively.

I hope this answers your query.

Please let me know if I can assist you further.

Thank you.

Medically reviewed byiCliniq medical review team

Published At March 26, 2025
Reviewed AtJune 5, 2025

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