How can I reduce my genetic risk of developing obesity?

Question

Hello doctor,

I am seeking advice on the role of genetics in obesity. I have a family history of obesity and I am looking for ways to mitigate her genetic predisposition. Can you provide information on the latest genetic research related to obesity, personalized treatment options, and any relevant clinical trials? Additionally, guidance on lifestyle changes and support resources would be greatly appreciated.

Thank you.

Answer 1

Hi,

Welcome to icliniq.com.

I understand your concern.

Genes play an important role in obesity. Based on genetics, obesity can be classified as monogenic and polygenic syndromes. But still, apart from genetics, lifestyle also plays an important role in the development of obesity. There is no such approved genetic therapy for obesity, but measures can be taken to prevent the development of obesity due to other factors.

I am summarizing the steps below:

Weight loss requires constant propulsive efforts. A simple formula for weight loss is a negative energy balance.
The calories spent should be more than the energy consumed. The deficit calorie energy will be obtained from the fat stored in our body, which are energy depot.
In this way, the fats get liquified, finally resulting in weight loss.
You can contact a dietician for an individualized meal plan with calorie intake calculations and the target for a BMI (body mass index) within the normal range.
Medications are available for weight loss, such as Orlistat and Semaglutide. However, these medicines cannot replace the lifestyle modifications as advised above. These medicines can be taken after consultation with a doctor.
Surgical options are gastric bypass surgery and liposuction, which can be undergone after consultation with an obesity specialist.

I hope this information helps you.

Revert in case of queries.

Regards.