HomeAnswersPsychiatryocdI read Depakote and Paroxetine can cause Parkinson's. How to stop them without withdrawal symptoms?

Will Depakote XR drug cause Parkinson's disease?


The following is an actual conversation between an iCliniq user and a doctor that has been reviewed and published as a Premium Q&A.

Medically reviewed by

Dr. Nithila. A

Published At June 12, 2019
Reviewed AtMay 2, 2024

Patient's Query

Hello doctor,

I am suffering from OCD and doctor prescribed Depakote XR 500 mg and Paroxetine CR 25 mg, which I am taking for last eight years. I read that these medicines can cause drug-induced Parkinson's. Please advise how to stop taking these medicines without withdrawal symptoms.


Welcome to icliniq.com.

I do not think that those medications can induce Parkinson's. Antipsychotic drugs are more common to induce extrapyramidal symptoms like Parkinson's. Still, if you want to stop it, then you need to taper off over months gradually. It may lead to worsening your OCD.

Patient's Query

Thank you doctor,

I have one more major problem. I am taking Nitrazepam 10 mg for last one year, and now I want to leave it. Please guide me in detail as to how to taper this medicine because Depakote XR 500 which I take is known to increase the effect of Nitrazepam several times. Can I taper off at home and how?


Welcome back to icliniq.com.

I think that you are taking Nitrazepam at night for sleep disturbance. You can taper off gradually. It makes a problem initially. You need to make it half (5 mg) for two weeks. Once you stable with it, then take 5 mg Nitrazepam for alternate days for another two weeks. Than take for twice a week for two weeks and continue as needed. I hope you understood.

Same symptoms don't mean you have the same problem. Consult a doctor now!

Dr. Vishal Anilkumar Gandhi
Dr. Vishal Anilkumar Gandhi


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