What is the risk in transferring the embryo with large ovary size?

Hello,

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With what I understand, you have suffered from ovarian hyperstimulation syndrome where ovarian size and volume has increased to 385cc, which is a lot and can cause sudden rupture and collapse in a patient. This is a known side effect of Follitropin injections if not related. Now that embryos have formed this cycle, they can be freezed for utilizing them in the next normal cycle. Presently they cannot be used as hyperstimulation syndrome can often be life threatening. I hope you have been admitted in the hospital and not at home. Please report to the hospital or IVF center and stay under medical supervision until the crisp is tided over. No embryo transfer with ovarian hyperstimulation.

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You have to understand that more than the PGS or even chromosomal analysis, it is the grade of frozen embryo and the day of embryo, which matters the most with regards to the success of an IVF cycle. Stage five blastocysts (hatching) with A grades with both the inner cell mass and the trophectoderm (written as 5AA) are thought to be ideal for transfer. You have not mentioned the grades of embryo transfer in your previous query as well, so I am unable to comment. However, lower or poor grade embryos have naturally lower chances of success. PGS is however done after grading of embryo (to be transferred) is good where a possible secondary genetic cause is being looked for which is or would make the embryo unsuitable for sustaining the fetal life ahead. I would request you to share all your hormonal profile reports and the ultrasound reports which you have already undergone before opting for IVF along with your husband's semen analysis report for review. Maybe you are not the candidate for IVF at all. We had many couples with failed IVF who conceived naturally after treatment. But one thing is for sure, please ask your doctor about the grading of embryos which were transferred earlier and the ones which are frozen.

Hello,

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I have seen the reports. (attachment removed to protect patient identity).

Out of 17 oocytes, 15 got fertilized and of which 13 went into embryo arrest and the remaining 4 were used of which 2 were transferred 4AA each and the remaining two were frozen. The possible reason for the failure of previous IVF even though good grade embryos were transferred is like late embryo arrest post day six inside the uterus. The reason for embryo arrest is yet unknown but in the lab over half of all arrested human embryos display chromosomal abnormalities (genetic defect). This means the commonest reason of in vitro developmental arrest is a genetic problem that prevents the growth of abnormal embryos. However, this is not the only reason for the arrest. In your case, the semen analysis shows 92 % abnormal forms and hence more number defective sperms with more defective embryos which in turn cause more embryo arrests. The chances of your frozen embryo transfer to succeed is also low considering your sperms are anyhow of poor quality. It is important that you get treated for your oligo-astheno-terato-zoospermia first and then can even try for natural conception even. Your wife has polycystic ovarian syndrome, which too is treatable with medications. Both of you shall require treatment for the next three months. Yourself with sperm energizers and multivitamins and your wife with three cycles of PCOD regimen. If you are anxious and are in a hurry for conception then you can continue to spend money on IVF without treatment and the chances of failures could be high. In my opinion, treatment is better before you plan to conceive.