Patient's Query
Hi doctor,
My father is 69 years old and has been living with Parkinson's disease for six years. We feel like we are slowly losing him to this illness. Initially, he was prescribed Levodopa-Carbidopa, which helped a lot, but now the wearing-off effect is very pronounced. He experiences only two to three hours of good mobility after each dose before the stiffness and tremors return intensely.
His neurologist added Ropinirole, but it has caused him to fall asleep suddenly during the day, which is dangerous. He often experiences freezing of gait, especially at doorways, and he had two falls last month, one of which resulted in a wrist fracture. Swallowing has become difficult for him, and a speech therapist has indicated that he is at high risk for aspiration.
Additionally, his blood pressure drops suddenly when he stands, going from 135 systolic while sitting to 88 while standing. The Parkinson's disease specialist explained that this is due to autonomic involvement. My father has also started experiencing visual hallucinations, such as seeing children in the room, which is distressing for the entire family. His sleep is very disturbed, and he has acted out his dreams violently, injuring my mother twice.
We consulted a psychiatrist, who is hesitant to prescribe antipsychotics because of his Parkinson's disease. His cognitive testing score on the MMSE was 22. I am wondering if deep brain stimulation is still an option at this stage of Parkinson's disease and what can be done safely to address his hallucinations.
Please guide.
Hi,
Welcome to icliniq.com.
Thank you for your query, and I can understand your concern.
For Parkinson's disease, it is important to keep consulting with your neurologist. If there are issues with freezing episodes, consider increasing the dosing frequency of Levodopa-Carbidopa, depending on the current regimen. If Ropinirole is not well tolerated, Pramipexole could be another option.
Regarding Parkinson's disease-related hallucinations and behavioral problems, I recommend starting Pimavanserin 34 mg, which is considered safe for managing behavioral and psychological symptoms associated with Parkinson's. I have seen promising results from this medication in some patients.
Deep brain stimulation (DBS) is usually contraindicated in advanced disease, especially for those experiencing psychosis or a poor response to levodopa-carbidopa, so I would not recommend it at this time.
I hope this information is helpful. Feel free to ask more questions.
Thank you.
Same symptoms don't mean you have the same problem. Consult a doctor now!
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