Q. Eptoin increases GGTP and ALP in cystic granulomatous patient. Is it normal?

Answered by
Dr. Hariharan V
and medically reviewed by Dr.Nithila A
Published on Sep 13, 2019

Hello doctor,

My father is 53-years-old, and he is taking medicine for cystic granulomatous for six years. Eptoin medicine does increase GGTP (140 now) ALP is 134. Kindly advice.

Dr. Hariharan V

Diabetology General Medicine Internal Medicine Nutritionist


Welcome to icliniq.com.

Eptoin (Phenytoin) causes many things like the slow performance of duties, confusion, and decreasing the intellect of a person. But it is a perfect drug to prevent fits. You are correct. The cause of increased GGT (gamma-glutamyl transferase) and ALP (alkaline phosphatase) is due to Eptoin only. They are liver enzymes, and they get elevated in liver disease.

Please do not be alarmed. Eptoin has not injured your father's liver. See, it is difficult to explain. The liver has many functions. The liver produces these enzymes. They elevate when liver cells are damaged. But they also raise when their production is more. Eptoin increases the production of these enzymes. It is entirely harmless, and their levels become normal when we stop Eptoin. But you cannot stop Eptoin. It is an important drug. So my suggestion is to do nothing and not to worry.

These enzymes can be elevated by drinking alcohol or if your father already has a liver problem. Kindly clarify those. If he is having any of these problems, please contact me.

1. Liver enzymes increase when the liver is damaged.

2. But your father does not have a liver problem.

3. The elevation of enzymes is due to increased production, stimulated by Eptoin.

4. No need to worry, and no drugs or any other thing are needed.

5. Please do these tests regularly in four-month intervals.

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