At 30, can sodium valproate affect my pregnancy?

Question

Hello, Doctor,

I have had a seizure disorder since I was 22, and now that I am 30 and planning to conceive, I am incredibly anxious. I am on Sodium valproate, which I have read might not be safe during pregnancy. I do not want to risk a relapse, but I also want to ensure I do not harm the baby. I am confused about whether I need to change my medication beforehand or if there’s a safer plan. Also, I have heard hormonal fluctuations can trigger seizures. Please tell me,

Will pregnancy increase my risk?
What about delivery and breastfeeding?
Are those safe with my condition?

Kindly help.

Thank you.

Answer 1

Hello,

Welcome to icliniq.com.

I read your query and can understand your concern.

Those planning to conceive should consult their doctor immediately. While it is possible to conceive while taking this medication, it carries significant risks to the developing fetus, including neural tube defects and developmental issues. The doctor will need to assess the individual situation, discuss potential risks and benefits, and may recommend alternative medications or strategies to minimize harm to the baby.

Hormonal fluctuations during pregnancy can trigger seizures in some women, particularly those with pre-existing epilepsy. While some women experience no change in their seizure frequency, others may see an increase or a change in seizure patterns.

These changes are linked to the significant hormonal shifts that occur during pregnancy, especially with estrogen and progesterone. If you take a valproate, it is not a reason to discontinue breastfeeding. No definite adverse reactions to valproic acid in breastfed infants have been found. But overall, it would be better if you consult a physician for

a physical and make further decisions about continuing the medicine or using alternative medicine before, during, and after delivery.

I hope this information helps you.

Feel free to ask further queries.

Thank you.