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What are the side effects of compounded Semaglutide?

This Premium Q&A, reviewed and published, features a real conversation between an iCliniq user and a physician.

Patient's Query

Hi doctor,

I started compounded Semaglutide eight weeks ago through a weight management clinic after insurance denied coverage for Wegovy. I am 54, BMI 41, with metabolic syndrome (hypertension, dyslipidemia, prediabetes with A1C 6.3). I lost 27 pounds so far, which is impressive, but I have been experiencing concerning side effects for the past few weeks. Having persistent nausea despite anti-nausea medications, severe constipation requiring prescription medications, fatigue so extreme I can barely function at work, and most concerning is the development of intermittent double vision and severe headaches—current dose 1.0 mg weekly with plans to increase to 1.7mg next month. Are visual disturbances known as a side effect of Semaglutide? Should I be concerned about possible impurities in the compounded version, given the FDA warnings I have read about? Would switching to an FDA-approved version potentially reduce these side effects? I also noticed my heart rate consistently elevated, which was not mentioned as a potential side effect. Should I continue increasing the dose, given these issues?

Kindly guide.

Thank you.

Answered by Dr. Lavi Madhur

Hello,

Welcome to icliniq.com.

I can understand your concern.

As you told, you are using Semaglutide, which is an anti-diabetic medication. It can severely lower your blood sugar levels, and also cause changes in your eye lens, causing intermittent blurring of vision. This has some potential side effects for the eyes, so kindly get a fund examination done and consult a general physician or endocrinologist if you are considering increasing the dose of the drug.

I hope this information will help you.

Thank you.

Investigations to be done

1. OCT (optical coherence tomography) macula. 2. Fundus examination.

Answered byDr. Lavi Madhur

Medically reviewed byiCliniq medical review team

Published At June 13, 2025
Reviewed AtJune 24, 2025

Same symptoms don't mean you have the same problem. Consult a doctor now!

Dr. Lavi Madhur
Dr. Lavi Madhur

Ophthalmology (Eye Care)

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