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What are the side effects of compounded Semaglutide?

This Premium Q&A, reviewed and published, features a real conversation between an iCliniq user and a physician.

Patient's Query

Hello doctor,

I started compounded Semaglutide two weeks ago for weight loss and have been experiencing some concerning side effects. I am 36 years old with a BMI of 36, and I have PCOS and insulin resistance. Since starting the medication, I have had intense nausea, constant headaches, and I even fainted at work yesterday. I have already lost 9 pounds, which is incredible, but I am very concerned about how severe these side effects are. My pharmacy says this is normal, but it feels extreme.

Should compounded medications be tested somehow? Is there a way to confirm if the dosage is correct? I can barely function at work, but I desperately need to lose this weight for my health. Unfortunately, my doctor, who prescribed it, is on vacation for another week.

Please advise.

Hello,

Welcome to icliniq.com.

I understand your concern.

Compounded Semaglutide has not been approved by the FDA (Food and Drug Administration). There is limited information available regarding its side effects and the potential severity of those effects. Currently, no substantial research has been conducted on compounded Semaglutide. Therefore, it is important that you consult your physician and consider switching to an FDA-approved treatment option, which may also be covered under your health insurance plan.

Common adverse effects of compounded Semaglutide include abdominal pain, constipation, diarrhea, rapid heartbeat, fatigue, and fainting. If you experience any of these symptoms, they may be related to the medication. It is recommended that you discontinue use immediately and seek emergency medical attention if you feel unwell. Potential complications may include low blood pressure, dehydration due to diarrhea, pancreatitis, and liver or kidney problems.

You can discuss FDA-approved alternatives, such as Wegovy (Semaglutide), with your physician. These medications are continuously monitored through ongoing research to evaluate their efficacy and safety. Your doctor may also help you explore ways to include such treatments under your health insurance coverage.

I hope this information addresses your concerns.

Thank you.

Answered byDr. Reema Wankar

Medically reviewed byiCliniq medical review team

Published At June 22, 2025
Reviewed AtJune 22, 2025

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