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Are there any prescription medicines that help quit smoking?

This Premium Q&A, reviewed and published, features a real conversation between an iCliniq user and a physician.

Patient's Query

Hello doctor,

I am 34 and trying hard to quit smoking after 15 years. I have cut down from a pack a day to three to four cigarettes. I have tried nicotine gum and patches, but still end up craving a smoke when I am stressed. Are there any prescription medicines that help without making you feel weird or sick? Also, I have heard about behavioral therapy. Does that work? I want to quit completely, but do not want to gain weight or feel worse mentally.

Kindly suggest.

Thank you.

Answered by Dr. Ahsanullah Niazai

Education:

MD

Professional Bio:

Dr. Ahsanullah Niazai is a General Physician with a strong commitment to patient-centered care and medical education. He is skilled in diagnosing and managing a wide range of acute and chronic health conditions. His areas of expertise include internal medicine, preventive healthcare, and clinical education, with a focus on promoting overall well-being and disease prevention.

This doctor is not available for online consultations on the platform anymore.

Hello,

Welcome to icliniq.com.

I can understand your concern.

First of all, congratulations on cutting down from a pack a day to just three to four cigarettes. That is a huge step in the right direction. Here are two main FDA (Food and Drug Administration) approved prescription options that help reduce cravings and withdrawal symptoms:

1. Varenicline (Chantix) - It partially stimulates nicotine receptors in your brain (so you get some dopamine boost), while also blocking nicotine from giving you a "hit" if you do smoke. It is one of the most effective medicines for quitting smoking aids.

Side effects of this medication are nausea (in some), insomnia in a few, but not everyone gets these, and they are often mild. And, the good point is that it can help reduce the pleasure you feel from smoking, making cigarettes less satisfying.

2: Bupropion (Zyban, Wellbutrin SR) - It is an antidepressant that also reduces nicotine cravings and withdrawal symptoms. It has less risk of weight gain (some even lose weight). It can help if you are worried about depression or mood issues. Side effects of this drug are dry mouth, insomnia, and mild anxiety (rare), but are usually well-tolerated.

You can use these with or without nicotine replacement (gum or patches); some people benefit most from a combination. And, regarding behavioural therapy, it significantly increases your chances of quitting, especially when combined with medications.

It helps with:

  1. Identifying your triggers (like stress, boredom, and social cues).

  2. Developing alternative coping strategies.

  3. Building motivation and accountability.

And regarding your weight gain concern, Bupropion is often a good choice if you want to avoid weight gain and support your mood. Mindful eating and light activity (even walking 30 minutes daily) help prevent weight gain.

Smoking withdrawal can cause temporary irritability or low mood, but it usually improves within two to four weeks. Long term, quitting smoking is linked to better mental health and reduced anxiety and depression.

Regarding follow-up: Always feel free to reach out without hesitation.

I hope this helps.

Kindly follow up if you have more concerns.

Thank you.

Medically reviewed by iCliniq medical review team
Published At September 23, 2025
Reviewed At September 25, 2025

Education:

MD

Professional Bio:

Dr. Ahsanullah Niazai is a General Physician with a strong commitment to patient-centered care and medical education. He is skilled in diagnosing and managing a wide range of acute and chronic health conditions. His areas of expertise include internal medicine, preventive healthcare, and clinical education, with a focus on promoting overall well-being and disease prevention.

This doctor is not available for online consultations on the platform anymore.

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Education:

MD

Professional Bio:

Dr. Ahsanullah Niazai is a General Physician with a strong commitment to patient-centered care and medical education. He is skilled in diagnosing and managing a wide range of acute and chronic health conditions. His areas of expertise include internal medicine, preventive healthcare, and clinical education, with a focus on promoting overall well-being and disease prevention.

This doctor is not available for online consultations on the platform anymore.

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