Is Tezspire effective in managing severe asthma symptoms?

Question

Hello doctor,

Last year, I was diagnosed with severe eosinophilic asthma, and I continue to face significant challenges. My current medications are only minimally alleviating my symptoms. Despite undergoing allergy shots and taking Singulair, Advair, and Spiriva, I have not experienced any substantial improvement. I am unable to engage in any physical activity and have suffered from pneumonia twice this year. My allergist mentioned a new medication called Tezspire, but appeared uncertain about it. Blood tests indicate elevated eosinophil levels, even with my ongoing treatment. At 38 years old, I am concerned about the possibility of permanent lung damage. I work in an office but find myself missing work weekly due to breathing difficulties. I would like to understand how Tezspire (Tezepelumab) differs from Nucala, which I previously tried. Honestly, could this medication finally enable me to breathe normally? How long would it take to determine if it is effective?

Kindly help.

Answer 1

Hello,

Welcome to icliniq.com.

Tezspire (Tezepelumab) differs significantly from Nucala. While Nucala (Mepolizumab, a type of monoclonal antibody) specifically targets IL-5 cells to inhibit Eosinophils, Tezspire works by blocking Thymic stromal lymphopoietin, thereby preventing various inflammatory and allergic responses. Indeed, it can help restore normal breathing. Research indicates a 50-70 percent decrease in attacks, leading to fewer hospital and emergency room visits, as well as a reduced reliance on steroids.

It may take 3 to 6 months for individuals to experience the full benefits.

I hope this information helps you.

Feel free to ask further queries.

Thank you.